{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:22:33Z","timestamp":1785288153924,"version":"3.55.0"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2021,3,19]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Background: The current study designed to analyze whether polymorphisms of miR-146a and miR-155 are related to Beh\u00e7et\u2019s disease (BD) in Egyptian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Methods: A total of 96 unrelated BD patients and 100 healthy subjects were genotyped for miR-146a (rs2910164) and miR-155(rs767649) using real-time polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results: the results showed significant elevation in the frequency of rs2910164 GG and CC genotypes in BD patients compared with controls (adjusted OR = 22.156, 95% CI (4.728-103.818); P &lt; 0.001 and adjusted OR = 40.358, 95% CI (8.928 -182.440); P &lt; 0.001, respectively). Also, rs2910164 G allele conferred a higher risk of developing BD (adjusted OR = 3.665, 95% CI (2.013-6.671); P &lt; 0.001). MiR-146a (rs2910164) polymorphism was a risk factor for susceptibility to BD in dominant, recessive and additive models of inheritance(All P &lt; 0.001), while, the miR-155(rs767649) polymorphism was a risk factor in recessive model only (P = 0.021). GG and CG genotypes of rs2910164 were associated with higher BDCAI activity and ocular involvement compared with CC genotype (P = 0.005 and P =0.004, respectively). Genotype AT of rs767649 was related to higher BDCAI activity (P = 0. 026) compared with TT or AA genotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Conclusion: The miR-146a (rs2910164) and miR-155(rs767649) were likely to play an important role in Egyptian population to develop BD and also influence disease severity.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms\/105349","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T22:03:38Z","timestamp":1616450618000},"source":"Crossref","is-referenced-by-count":2,"title":["MiR-146a and miR-155 polymorphisms in Egyptian patients with Behcet\u2019s disease"],"prefix":"10.5114","author":[{"given":"Omayma","family":"Abdelaleem","sequence":"first","affiliation":[{"name":"Faculty of medicine , Fayoum university"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfat","family":"Shaker","sequence":"additional","affiliation":[{"name":"Faculty of medicine , Cairo university"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2021,3,19]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-105349-62928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-105349-62928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T14:23:12Z","timestamp":1635517392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/MiR-146a-and-miR-155-polymorphisms-in-Egyptian-patients-with-Behcet-s-disease,105349,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,19]]},"references-count":0,"alternative-id":["105349"],"URL":"https:\/\/doi.org\/10.5114\/aoms\/105349","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,19]]}}}