{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:25:48Z","timestamp":1765268748273},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2021,3,24]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Autologous saphenous vein (SV) and internal mammary artery (IMA) are used as bypass conduits during coronary artery bypass graft surgery. Vasospasm of the arterial and venous grafts may constitute a significant clinical problem. Pretreatment with a vasodilator drug of the graft ex vivo or intraluminal injection before implantation may be used for spasm prophylaxis. This in-vitro study was designed to assess the vasoactive effects and time-dependent changes of botulinum toxin A (BTX-A) and papaverine pretreatment on vasospasm of human SV and IMA grafts. Also histomorphology of the vessels were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>SV and IMA segments were suspended in organ baths and isometric contraction responses to two different concentrationsof 5-hydroxytryptamine (5-HT) and endothelin-1 (ET-1) were recorded after incubation with two different concentrations of BTX-A and papaverine at two time points (0 hours and 2nd hour).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results suggest that; 1) incubation with BTX-A and papaverine relaxes both SV and IMA rings contracted with 5-HT and ET-1, 2) duration of the relaxant effect of BTX-A lasts longer than papaverine, 3) no apparent histomorphologic changes are observed in the grafts under light microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that in human SV and IMA grafts, pretreatment with both BTX-A and papaverine are safe and have a potent inhibitory effect depending on the vessel and vasoconstrictor agent. Long lasting vasodilatory effect of BTX-A on vascular smooth muscle may provide promising results for preventing venous and arterial graft spasm.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms\/110157","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:11:14Z","timestamp":1616544674000},"source":"Crossref","is-referenced-by-count":4,"title":["Effects of botulinum toxin A and papaverine on human saphenous vein and internal mammary artery grafts: an in vitro study"],"prefix":"10.5114","author":[{"given":"Ipek","family":"Duman","sequence":"first","affiliation":[{"name":"Necmettin Erbakan University, Meram Faculty of Medicine, Department of Medical Pharmacology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6mer","family":"Tanyeli","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University, Meram Faculty of Medicine, Department of Cardiovascular Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuksel","family":"Dereli","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University, Meram Faculty of Medicine, Department of Cardiovascular Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pembe","family":"Oltulu","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University, Department of Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"Toy","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University, Department of Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse","family":"Sahin","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University, Meram Faculty of Medicine, Department of Medical Pharmacology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2021,3,24]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-110157-63081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-110157-63081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T14:22:35Z","timestamp":1635517355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Effects-of-botulinum-toxin-A-and-papaverine-on-human-saphenous-vein-and-internal,110157,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,24]]},"references-count":0,"alternative-id":["110157"],"URL":"https:\/\/doi.org\/10.5114\/aoms\/110157","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,24]]}}}