{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T18:25:11Z","timestamp":1649096711529},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2021,1,31]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Interferon (IFN)-\u03b2 is known as an\u00a0environmental trigger for the occurrence of\u00a0autoimmune thyroid disease (AITD). However, the\u00a0association of\u00a0another type-1 IFN, IFN-\u03b2, with AITD is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In the\u00a0study, we explored the\u00a0association of\u00a0serum IFN-\u03b2 levels with AITD in an\u00a0ethnic Chinese (i.e., Taiwanese) population. We enrolled 160 patients with Graves\u2019 disease (GD), 47 patients with Hashimoto\u2019s thyroiditis (HT), and 119 healthy controls. Serum IFN-\u03b2 and B-cell activating factor (BAFF) levels were quantified in healthy controls at the\u00a0baseline and in patients with AITD either prior to receiving medication or while under medication. Thyroid function and thyroid-stimulating hormone receptor antibody (TSHRAb) levels were measured at the\u00a0time of\u00a0serum collection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum IFN-\u03b2 levels were lower in the\u00a0HT group than in the\u00a0control group (p\u00a0=\u00a00.031). A\u00a0significant inverse correlation was observed between IFN-\u03b2 and TSHRAb levels in men with GD (r\u00a0=\u00a0\u20130.433, p\u00a0=\u00a00.044). Serum IFN-\u03b2 levels were also negatively associated with BAFF levels in men with GD, HT, and AITD (r\u00a0=\u00a0\u20130.320, p\u00a0=\u00a00.032; r\u00a0=\u00a0\u20130.817, p\u00a0=\u00a00.047; and r\u00a0=\u00a0\u20130.354, p\u00a0=\u00a00.011, respectively), but not in women with GD, HT, or AITD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum IFN-\u03b2 levels were lower in HT patients. Correlations of serum IFN-\u03b2 with TSHRAb and BAFF levels were found to be gender-specific. Further well-designed studies with larger sample sizes are required to confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms\/110164","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T09:25:45Z","timestamp":1614763545000},"source":"Crossref","is-referenced-by-count":0,"title":["Differential serum interferon-\u03b2 levels in autoimmune thyroid diseases"],"prefix":"10.5114","author":[{"given":"Chao-Wen","family":"Cheng","sequence":"first","affiliation":[{"name":"Graduate Institute of\u00a0Clinical Medicine, College of\u00a0Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Traditional Herb Medicine Research Center, Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kam-Tsun","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of\u00a0Endocrinology and Metabolism, Department of\u00a0Internal Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Fang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of\u00a0Family Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-I","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of\u00a0Endocrinology and Metabolism, Department of\u00a0Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan"},{"name":"Division of\u00a0Endocrinology and Metabolism, Department of\u00a0Internal Medicine, School of\u00a0Medicine, College of\u00a0Medicine, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiunn-Diann","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of\u00a0Endocrinology and Metabolism, Department of\u00a0Internal Medicine, School of\u00a0Medicine, College of\u00a0Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Division of\u00a0Endocrinology, Department of\u00a0Internal Medicine, Shuang Ho Hospital, \nTaipei Medical University, New Taipei City 23561, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2021,1,31]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-110164-61414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-110164-61414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T14:22:36Z","timestamp":1635517356000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Differential-serum-interferon-levels-in-autoimmune-thyroid-diseases,110164,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,31]]},"references-count":0,"alternative-id":["110164"],"URL":"https:\/\/doi.org\/10.5114\/aoms\/110164","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,31]]}}}