{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:43:56Z","timestamp":1747226636998,"version":"3.40.5"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2021,3,21]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hypocalcaemia remains the most common postoperative complication after total thyroidectomy.\nThe purpose of the study was to evaluate the clinical usefulness of routine preoperative oral calcium and vitamin D supplementation in the prevention of hypocalcaemia after total thyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>One hundred fifty-three consecutive patients with nontoxic multinodular goitre were randomly assigned to routinely receive (group B) or not to receive (group A) calcium carbonate (3 g\/d) and alfacalcidol (1 \u00b5g\/d) on the day before surgery and calcium carbonate (1 g\/d) and alfacalcidol (1 \u00b5g\/d) taken once in the morning on the day of operation.\nTheir preoperative 25-hydroxyvitamin D (25-OHD) levels, hypocalcemic symptoms, serum calcium and parathyroid hormone (iPTH) levels were determined 6 and 24 hour postoperatively and 6 weeks after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Symptomatic hypocalcaemia was observed in 41\/153(26.79%) patients. The incidence of symptomatic hypocalcaemia was significantly lower in the supplemented group than in the group not receiving supplementation: 10 of 77 participants (12.99%) versus 31 of 76 patients (40.79%) (p&lt;0.05).\nThe rates of laboratory and severe hypocalcaemia (corrected calcium &lt;2.0 mmol\/l) were 67.11% and 28.95% in group A and 50.65% and 9.09% in group B, respectively (p=0.04, p&lt;0.05).\nThere were no significant differences between groups A and B in corrected calcium levels after surgery and postoperative decreases in corrected calcium levels (p=0.06). 112(73.20%) participants had 25-OHD&lt;20 ng\/ml. Vitamin D levels did not influence corrected calcium level changes (p=0.98).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral supplementation of calcium and alfacalcidol may help in the prevention of postthyroidectomy hypocalcaemia. Vitamin D deficiency was widespread among operated patients.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms\/121044","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T22:03:38Z","timestamp":1616450618000},"source":"Crossref","is-referenced-by-count":0,"title":["Is preoperative calcium and vitamin D supplementation effective in prevention of postoperative hypocalcaemia in thyroidectomised patients?"],"prefix":"10.5114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4470-3659","authenticated-orcid":false,"given":"Anna","family":"Grzegory","sequence":"first","affiliation":[{"name":"Department of General and Oncological Surgery, Medical University of Lodz, Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lech","family":"Pomorski","sequence":"additional","affiliation":[{"name":"Department of General and Oncological Surgery, Medical University of Lodz, Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8031-3319","authenticated-orcid":false,"given":"Konrad","family":"Pagacz","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karol","family":"Sieniawski","sequence":"additional","affiliation":[{"name":"Department of General and Oncological Surgery, Medical University of Lodz, Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Kaczka","sequence":"additional","affiliation":[{"name":"Department of General and Oncological Surgery, Medical University of Lodz, Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2021,3,21]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-121044-62979","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-121044-62979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T14:18:21Z","timestamp":1635517101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Is-preoperative-calcium-and-vitamin-D-supplementation-effective-in-prevention-of,121044,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,21]]},"references-count":0,"alternative-id":["121044"],"URL":"https:\/\/doi.org\/10.5114\/aoms\/121044","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"type":"print","value":"1734-1922"},{"type":"electronic","value":"1896-9151"}],"subject":[],"published":{"date-parts":[[2021,3,21]]}}}