{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T10:59:29Z","timestamp":1648810769057},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2021,3,21]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Systemic sclerosis (SSc) is a chronic, autoimmune connective tissue disease characterized by immune system activation, vasculopathy, and collagen accumulation. Despite progressive fibrosis of the vasculature, compensatory angiogenesis is impaired. The cause of the shift towards anti-angiogenesis observed in SSc is unknown. The IL-17 cytokine family participates in the pathogenesis of SSc and angiogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Our study aimed to evaluate levels and find relationships between the levels of proangiogenic cytokines and cytokines from the IL-17 family in 42 SSc subjects and 20 healthy controls. VEGF, PlGF, HGF, TGF\u03b21, GM-CSF, IL-17A, IL-17B, IL-17E and IL-17F were quantified in the sera of all participants by ELISA sandwich kits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly higher mean concentrations of PlGF compared to controls - mean value (19.3 pg\/ml in the SSc group vs. 11.4 pg\/ml in the control group; p&lt;0.001) and of HGF (1931 pg\/ml in the SSc group vs. 1483 pg\/ml in controls; p&lt;0.05). Mean serum TGF\u03b21 level was also significantly lower in the SSc group (781 pg\/ml) than controls (35991 pg\/ml; p&lt;0.001). Among the IL-17 family, significantly higher mean concentrations of IL-17B (67.0 pg\/ml vs. 2.6 pg\/ml in controls; p&lt;0,001), IL-17E (8.0 pg\/ml vs 0.64 pg\/ml in controls; p&lt;0.001) and IL-17F (0.42 pg\/ml vs. 0.0 pg\/ml in controls; p&lt; 0.01) were detected. Serum concentrations of HGF and PlGF correlated with the concentrations of IL17A, IL-17B, and IL-17E.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, our findings indicate that selected cytokines from the IL17 family participate in the pathogenesis of SSc and are responsible for the vascular abnormalities associated with this disorder.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms\/128102","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T22:03:38Z","timestamp":1616450618000},"source":"Crossref","is-referenced-by-count":0,"title":["Interplay between IL-17 family members and angiogenic cytokines in subjects with systemic sclerosis."],"prefix":"10.5114","author":[{"given":"Agata","family":"Liszewska","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Lodz 90-647 Lodz, Plac J. Hallera 1\/6, Poland, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Robak","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Lodz 90-647 Lodz, Plac J. Hallera 1\/6, Poland, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Wo\u017aniacka","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Lodz 90-647 Lodz, Plac J. Hallera 1\/6, Poland, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslaw","family":"Bogaczewicz","sequence":"additional","affiliation":[{"name":"University of Economics and Human Sciences in Warsaw, ul. Okopowa 59, 01-043 Warsaw, Poland"},{"name":"Department of Dermatology and Venereology, Medical University of Lodz,  Plac J. Hallera 1\/6, 90-647 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u017cena","family":"Dziankowska-Bartkowiak","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Lodz 90-647 Lodz, Plac J. Hallera 1\/6, Poland, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zofia","family":"Gerlicz-Kowalczuk","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Pediatric Dermatology and Dermatological Oncology, Medical University of Lodz, Poland, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2021,3,21]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-128102-62964","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-128102-62964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T14:15:51Z","timestamp":1635516951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Interplay-between-IL-17-family-members-and-angiogenic-cytokines-in-subjects-with,128102,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,21]]},"references-count":0,"alternative-id":["128102"],"URL":"https:\/\/doi.org\/10.5114\/aoms\/128102","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,21]]}}}