{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:13:17Z","timestamp":1781133197285,"version":"3.54.1"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2021,5,10]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Markers of iron homeostasis are related to insulin resistance\n(IR) in adults. However, studies in children and adolescents are scarce and\nshow contradictory results. The aim was to evaluate the potential relationship between iron status markers and IR. Additionally, no previous study has\nexplored the mutual effect of biomarkers of iron homeostasis and inflammation (i.e. high sensitivity C-reactive protein (hsCRP)), and adipokines (i.e.\nretinol-binding protein 4 (RBP4)) on IR in the cohort of adolescent girls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A total of 60 girls age between 16 and 19 years were\nincluded in the study. Serum levels of ferritin, transferrin, soluble transferrin\nreceptor (sTfR), hsCRP, and RBP4 were measured by immunonephelometry.\nHomeostasis model assessment of insulin resistance (HOMA-IR) and iron\nhomeostasis indexes were calculated. Univariate and multivariate binary logistic regression analysis were used to investigate the possible independent\nassociations of the examined biomarkers. Principal component analysis was\nused to examine their mutual effect on HOMA-IR in the studied girls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ferritin, sTfR, hsCRP and RBP4 were significant predictors for higher HOMA-IR in univariate analysis (p = 0.020, p = 0.009, p = 0.007, p =\n0.003, respectively). Multivariate regression analysis after adjustment for\nwaist circumference (WC) showed that serum sTfR levels remained positively associated with higher HOMA-IR (p = 0.044). Factorial analysis revealed\nthat the obesity-inflammation related factor (i.e., WC and hsCRP) and adipokine-acute phase protein related factor (i.e., RBP4 and ferritin) showed\nsignificant differences between HOMA-IR &lt; 2.5 and HOMA-IR \u2265 2.5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum sTfR levels are independently associated with HOMA-IR,\nwhereas higher serum ferritin levels together with higher RBP4 are related\nto higher HOMA-IR in adolescent girls.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms\/132757","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T14:04:49Z","timestamp":1620655489000},"source":"Crossref","is-referenced-by-count":13,"title":["Serum soluble transferrin receptor levels are\nindependently associated with homeostasis model\nassessment of insulin resistance in adolescent girls"],"prefix":"10.5114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7870-0996","authenticated-orcid":false,"given":"Aleksandra","family":"Klisic","sequence":"first","affiliation":[{"name":"Primary Health Care Center, University of Montenegro-Faculty of Medicine, Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nebojsa","family":"Kavaric","sequence":"additional","affiliation":[{"name":"Primary Health Care Center, University of Montenegro-Faculty of Medicine, Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Kotur","sequence":"additional","affiliation":[{"name":"Department for Medical Biochemistry, University of Belgrade, Faculty of Pharmacy, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Ninic","sequence":"additional","affiliation":[{"name":"Department for Medical Biochemistry, University of Belgrade, Faculty of Pharmacy, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2021,5,10]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-132757-65021","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-132757-65021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T14:14:39Z","timestamp":1635516879000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Serum-soluble-transferrin-receptor-levels-are-nindependently-associated-with-homeostasis,132757,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,10]]},"references-count":0,"alternative-id":["132757"],"URL":"https:\/\/doi.org\/10.5114\/aoms\/132757","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,10]]}}}