{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:13:10Z","timestamp":1791144790324,"version":"4.1.0"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2022,1,17]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Endothelin-1 (ET-1) gene polymorphisms are implicated in pathogenesis of idiopathic pulmonary arterial hypertension<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We studied ET-1 (Lys198Asn and 3A\/4A) and endothelin receptor A (ETA) gene (His323His) polymorphisms in 123 subjects with pulmonary hypertension associated with rheumatic mitral valve disease (PH-MVD) and 123 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mutant homozygous Asn\/Asn genotype in Lys198Asn and T\/T genotype in His323His polymorphism was more prevalent in PH-MVD group. Presence of Asn\/Asn genotype was significantly associated with increased risk (odds ratio 3.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ET-1 and ET&lt;sub&gt;A&lt;\/sub&gt; gene polymorphisms are prevalent in PH-MVD group suggesting that they may predispose to the development of PH.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms\/144630","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T23:32:40Z","timestamp":1642548760000},"page":"260-266","source":"Crossref","is-referenced-by-count":5,"title":["Endothelin-1 gene and endothelin receptor A\u00a0gene polymorphisms in severe pulmonary hypertension associated with rheumatic mitral valve disease"],"prefix":"10.5114","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3712-0271","authenticated-orcid":false,"given":"Pratishtha","family":"Mehra","sequence":"first","affiliation":[{"name":"Department of Cardiology, G.B. Pant Institute of Postgraduate Medical Education and Research, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3762-2618","authenticated-orcid":false,"given":"Vimal","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, G.B. Pant Institute of Postgraduate Medical Education and Research, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Department of Cardiology, G.B. Pant Institute of Postgraduate Medical Education and Research, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Sukhija","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilbert","family":"Aronow","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westchester Medical Center and New York Medical College, Valhalla, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2022,1,17]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-144630-71934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-144630-71934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T23:32:45Z","timestamp":1642548765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Endothelin-1-gene-and-endothelin-receptor-A-gene-polymorphisms-in-severe-pulmonary,144630,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,17]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"alternative-id":["144630"],"URL":"https:\/\/doi.org\/10.5114\/aoms\/144630","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,17]]}}}