{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T07:39:26Z","timestamp":1763105966747,"version":"3.40.5"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>To investigate the expression and treatment of chemokine CXCL12 and its receptor CXCR4\/CXCR7.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The liver cirrhosis hypersplenism model of rats was made with CCL4, and then was detected by immunohistochemistry, Western blot and qRT-PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The area of spleen fibrosis in the model group was significantly larger than that in the control group (p &lt; 0.01), and the expression of CXCL12, CXCR4 and CXCR7 in the model group was significantly higher than that in the control group (p &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CXCL12-CXCR4\/CXCR7 is abnormally high in splenic fibrosis, and blocking its high expression can slow down the occurrence of hypersplenism.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms\/170910","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T13:38:52Z","timestamp":1694093932000},"page":"1569-1575","source":"Crossref","is-referenced-by-count":2,"title":["Expression of CXCL12-CXCR4\/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance"],"prefix":"10.5114","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0451-399X","authenticated-orcid":false,"given":"Yunfu","family":"Lv","sequence":"first","affiliation":[{"name":"Department of General Surgery, Hainan General Hospital (Hainan Medical College Affiliated People\u2019s Hospital), Haikou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yejuan","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center of Hainan Women and Children\u2019s Medical Center, Haikou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiaoYu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hainan General Hospital (Hainan Medical College Affiliated People\u2019s Hospital), Haikou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hainan General Hospital (Hainan Medical College Affiliated People\u2019s Hospital), Haikou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-1980","authenticated-orcid":false,"given":"Min","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hainan General Hospital (Hainan Medical College Affiliated People\u2019s Hospital), Haikou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2023,8,25]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-170910-94250","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-170910-94250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T13:39:58Z","timestamp":1694093998000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Expression-of-CXCL12-CXCR4-CXCR7-chemokines-in-splenic-fibrosis-of-cirrhotic-spleen,170910,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,25]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023]]}},"alternative-id":["170910"],"URL":"https:\/\/doi.org\/10.5114\/aoms\/170910","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"type":"print","value":"1734-1922"},{"type":"electronic","value":"1896-9151"}],"subject":[],"published":{"date-parts":[[2023,8,25]]}}}