{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:22:46Z","timestamp":1790716966355,"version":"4.1.0"},"reference-count":30,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Limited data exist on long-term follow-up of severe aortic stenosis (SAS) patients who have undergone transcatheter aortic valve implantation (TAVI) with a new generation, balloon expandable Myval transcatheter heart valve (THV). Thus, we sought to investigate the performance and 2-year clinical outcome of the Myval THV system based on Valve Academic Research Consortium-3 (VARC-3) criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A multi-centre, registry-based, observational study was conducted, which included 207 consecutive degenerative SAS patients, from Turkey (n = 128), Italy (n = 58), and Greece (n = 21) (mean [standard deviation] 81 (7) years, 94 [45%] men; 73% NYHA III or IV; EuroSCORE II 5.2% [2.4%]); all patients underwent TAVI with Myval. Patients were followed up at 1 year and 2 years after implantation. Clinical and procedural outcomes were defined according to VARC-3 criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Technical success was observed in 204 (99%), device success was observed in 189 (91%), early safety was observed in 161 (78%), and clinical efficacy was observed in 163 (79%) patients. The 30-day death rate was 7.7%; of these, 3.4% were due to cardiovascular reasons. All-cause and cardiovascular mortality rates were 9.7% and 4.3% at 1-year follow-up, and 17.4% and 9.7% at 2-year follow-up, respectively. Incidence of \u2265 moderate paravalvular leak (PVL) at 30 days, 1 year and 2 years of follow-up were 3.4%, 4.3% and 4.8%. A total of 11.1% of patients required a permanent pacemaker implantation (PPI) at 30 days after implantation, while the cumulative rate of PPI at 2 years was 12.1%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this cohort of patients with SAS, the Myval was found to be safe and effective in up to 2 years of follow-up.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms\/176937","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T13:08:56Z","timestamp":1713877736000},"page":"410-419","source":"Crossref","is-referenced-by-count":8,"title":["Clinical outcomes of the Myval transcatheter heart valve system in patients with severe aortic valve stenosis: a two-year follow-up observational study"],"prefix":"10.5114","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5312-0258","authenticated-orcid":false,"given":"Teoman","family":"Kilic","sequence":"first","affiliation":[{"name":"Kocaeli University Medical Faculty, Department of Cardiology, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Ielasi","sequence":"additional","affiliation":[{"name":"U.O. Cardiologia Ospedalirea, IRCCSOspedale Galeazzi Sant\u2019Ambrogio, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlasis","family":"Ninios","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Interbalkan European Medical Center, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8108-6376","authenticated-orcid":false,"given":"Levent","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Health Sciences, Trabzon Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demosthenes","family":"Panagiotakos","sequence":"additional","affiliation":[{"name":"School of Health Sciences and Education, Harokopio University, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1880-5280","authenticated-orcid":false,"given":"Gokhan","family":"Yerlikaya","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Health Sciences, Trabzon Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4369-6146","authenticated-orcid":false,"given":"Ahmet","family":"Ozderya","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Health Sciences, Trabzon Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Montonati","sequence":"additional","affiliation":[{"name":"U.O. Cardiologia Ospedalirea, IRCCSOspedale Galeazzi Sant\u2019Ambrogio, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Tespili","sequence":"additional","affiliation":[{"name":"U.O. Cardiologia Ospedalirea, IRCCSOspedale Galeazzi Sant\u2019Ambrogio, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senol","family":"Coskun","sequence":"additional","affiliation":[{"name":"Kocaeli University Medical Faculty, Department of Cardiology, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayfun","family":"Sahin","sequence":"additional","affiliation":[{"name":"Kocaeli University Medical Faculty, Department of Cardiology, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Ninios","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Interbalkan European Medical Center, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Vlasopoulou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National and Kapodistrian University of Athens, Hippokration General Hospital, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7078-4021","authenticated-orcid":false,"given":"Ali Hakan","family":"Konus","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Health Sciences, Trabzon Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-4603","authenticated-orcid":false,"given":"Selim","family":"Kul","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Health Sciences, Trabzon Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3327-7850","authenticated-orcid":false,"given":"Ali Riza","family":"Akyuz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Health Sciences, Trabzon Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"ref-1168297","unstructured":"Kilic T, Yilmaz I. 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