{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:37:44Z","timestamp":1790707064888,"version":"4.1.0"},"reference-count":13,"publisher":"Termedia Sp. z.o.o.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Atrophic gastritis and intestinal metaplasia are precursor lesions of gastric cancer. The aim of this study was to determine the usefulness of the biomarkers pepsinogen I(PgI), pepsinogen II (PgII), gastrin-17, and H. pylori antibodies in the identification of precursor lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 129 patients with gastric symptoms. The biomarker status was determined using GastroPanel by means of the ELISA-technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Biomarkers detected atrophy in 14% of the subjects, and 49.6% had positive antibodies for H. pylori. A PgI\/PgII ratio &lt; 3 was an important risk biomarker for precursor lesions in our population (OR = 9.171, 95% CI: 1.723\u201348.799, p = 0.009); however, biomarkers showed low accuracy with histopathological study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the Western Mexican population, precursor lesions (AG, IM) are common in adults (45%) with dyspepsia but infrequent in children (8%). H. pylori infection was detected in 41.3% of adults and 16.0% of children. Of the studied biomarkers, a PgI\/PgII ratio &lt; 3 was an important risk factor for precursor lesions such as AG or IM in our population, with an OR of 9.171 (95% CI: 1.723\u201348.799, p = 0.009).<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms\/189971","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T13:31:46Z","timestamp":1720445506000},"page":"1016-1021","source":"Crossref","is-referenced-by-count":13,"title":["Pepsinogen I, pepsinogen II, gastrin-17, and Helicobacter pylori serological biomarkers in the diagnosis of precursor lesions of gastric cancer"],"prefix":"10.5114","volume":"20","author":[{"given":"Josefina Yoaly","family":"S\u00e1nchez-L\u00f3pez","sequence":"first","affiliation":[{"name":"Divisi\u00f3n de Gen\u00e9tica, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente, Instituto Mexicano del Seguro Social, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1263-927X","authenticated-orcid":false,"given":"Luis Carlos","family":"D\u00edaz-Herrera","sequence":"additional","affiliation":[{"name":"Servicio de Gastroenterolog\u00eda, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5482-1611","authenticated-orcid":false,"given":"Lourdes del Carmen","family":"Rizo-de la Torre","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Medicina Molecular, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente, Instituto Mexicano del Seguro Social, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"ref-1210035","doi-asserted-by":"crossref","unstructured":"Ricuarte O, Gutierrez O, Cardona H, Kim JG, Graham DY, El-Zimaity HM. 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Transl Gastroenterol Hepatol 2022; 7: 8.","DOI":"10.21037\/tgh.2020.03.03"},{"key":"ref-1210039","doi-asserted-by":"crossref","unstructured":"Pogoriler J, Kamin D, Goldsmith JD. Pediatric non-Helicobacter pylori atrophic gastritis: a case series. Am J Surg Pathol 2015; 39: 786-92.","DOI":"10.1097\/PAS.0000000000000378"},{"key":"ref-1210040","doi-asserted-by":"crossref","unstructured":"Peleteiro B, Bastos A, Ferro A, Lunet N. Prevalence of Helicobacter pylori infection worldwide: a systematic review of studies with national coverage. Dig Dis Sci 2014; 59: 1698-709.","DOI":"10.1007\/s10620-014-3063-0"},{"key":"ref-1210041","doi-asserted-by":"crossref","unstructured":"Agin M, Batun I, Ozdemir S, Doran F, Tumgor G. Prevalence of Helicobacter pylori in Turkish children with celiac disease and its effect on clinical, histopathological, and laboratory parameters. 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