{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:29:49Z","timestamp":1793158189465,"version":"4.5.0"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"abstract":"Introduction<\/jats:title>Chronic Obstructive Pulmonary Disease (COPD) has shown a rising trend in morbidity and mortality over the years, leading to a growing economic burden globally. The aim of this study was to establish a predictive score for assessing the risk of death in patients with severe acute exacerbations of COPD (AECOPD) to help clinicians evaluate the condition and prognosis of patients.<\/jats:p><\/jats:sec>Material and methods<\/jats:title>Patients hospitalized for severe AECOPD were consecutively included. All patients were randomly assigned to the developmental and validation cohorts in a 7:3 ratio. We identified independent prognostic factors for in-hospital mortality in development cohort by univariate analysis and multivariate logistic regression analysis. In validation cohort, the predictive power of the new score was verified and compared to the other four scores.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 488 patients with severe AECOPD who were hospitalized from January 2011 to October 2022 were included. The mean age was (78.0 \u00b1 8.2) years and 361 (74.0%) of the patients were male. The development cohort included 342 patients, 40 of whom died during hospitalization. The five independent risk factors associated with in-hospital mortality according to multi-factorial regression analysis were WBC > 10 \u00d7 109\/L, lymphocyte count < 0.8 \u00d7 109\/L, age > 80 years, confusion, and chronic heart failure. In validation cohort, the new prediction scores had good predictive power (AUC=0.826, 95% CI: 0.724-0.928) and performed more strongly than other clinical prediction scores.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The new predictive score is a simple and effective way to predict mortality in hospitalized patients with severe AECOPD.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms\/191299","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T19:51:33Z","timestamp":1721937093000},"source":"Crossref","is-referenced-by-count":4,"title":["Predictive score for in-hospital mortality in patients with severe acute exacerbations of COPD"],"prefix":"10.5114","author":[{"given":"Yanlu","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0117-1248","authenticated-orcid":false,"given":"Yanyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Xing","sequence":"additional","affiliation":[{"name":"Research Center of Occupational Medicine, Peking University Third Hospital, Beijing, 100191, China, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Jinan University (also known as Guangzhou Overseas Chinese Hospital and the First Clinical Medical College of Jinan University), Guangzhou, P.R. China, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"huanyu","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0437-3766","authenticated-orcid":true,"given":"Yanfei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2024,7,25]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-191299-112674","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-191299-112674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T19:51:37Z","timestamp":1721937097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Predictive-score-for-in-hospital-mortality-in-patients-with-severe-acute-exacerbations,191299,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,25]]},"references-count":0,"alternative-id":["191299"],"URL":"https:\/\/doi.org\/10.5114\/aoms\/191299","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,25]]}}}