{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:44:38Z","timestamp":1770965078276,"version":"3.50.1"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Previous studies have linked placental weight (PW) to cardiovascular diseases, but the causality and potential mediators underlying this relationship are still unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We conducted Mendelian randomization (MR) analysis via summary statistics from genome-wide association studies (GWAS), including PW adjusted for sex, 21 candidate mediators and atherosclerotic cardiovascular disease (ASCVD), which includes coronary heart disease (CHD) and ischemic stroke (IS).Two-step MR was employed to identify and assess the mediation proportion of potential mediators in the association between PW and ASCVD. Additionally, we conducted a repeated analysis using PW adjusted for gestational age and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariable MR (UVMR) analysis revealed that for each 1-SD decrease in fetal genotype-determined PW adjusted for sex only, the risk of CHD increased by 24% (95% CI: 1.05\u20131.46) and the risk of large artery stroke (LAS) increased by 46% (95% CI: 1.13\u20131.89). Similar results were obtained in repeated analyses. The mediation MR analysis revealed that the causal relationship between fetal genotype-determined PW and CHD risk was primarily mediated by birthweight, type 2 diabetes, and education, each mediating 3.66% to 40.80% of the total effect. The causal relationship between fetal genotype-determined PW and LAS risk was mediated mainly by type 2 diabetes, which accounted for 22.11% of the total effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study elucidated a unidirectional causal relationship between lower PW and a greater ASCVD risk, with factors such as birthweight, type 2 diabetes, and education mediating the association between PW and ASCVD.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms\/194244","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T15:40:56Z","timestamp":1729957256000},"source":"Crossref","is-referenced-by-count":1,"title":["The causal effects of placental weight on atherosclerotic cardiovascular disease:  a Mendelian randomization and mediation analysis"],"prefix":"10.5114","author":[{"given":"Dongyue","family":"Chen","sequence":"first","affiliation":[{"name":"Tianjin Medical University General Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Tianjin Medical University General Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilin","family":"Fan","sequence":"additional","affiliation":[{"name":"Tianjin Medical University General Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Medical University General Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songtao","family":"Shou","sequence":"additional","affiliation":[{"name":"Tianjin Medical University General Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Peng","sequence":"additional","affiliation":[{"name":"Tianjin Medical University General Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Yang","sequence":"additional","affiliation":[{"name":"Tianjin Medical University General Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Hou","sequence":"additional","affiliation":[{"name":"Tianjin Medical University General Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2024,10,26]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-194244-115626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-194244-115626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T15:40:59Z","timestamp":1729957259000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/The-causal-effects-of-placental-weight-on-atherosclerotic-cardiovascular-disease,194244,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,26]]},"references-count":0,"alternative-id":["194244"],"URL":"https:\/\/doi.org\/10.5114\/aoms\/194244","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,26]]}}}