{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T02:49:00Z","timestamp":1788058140381,"version":"build-2784847793"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"abstract":"<jats:p>Cytokines are small and membrane-bound protein-based cell signaling molecules that aid cell-to-cell communication in physiological and pathological processes. TNF-\u03b1 is a pleiotropic cytokine, it is regarded as a principal cytokine in the acute and chronic phases of the immune and inflammatory response. TNF-\u03b1 has been demonstrated to play a role in neuroplasticity and myelination, as well as excitotoxicity, neuroinflammation, and damage to the blood-brain barrier. The involvement of TNF-\u03b1 in the etiology of Parkinson\u2019s disease, both in its early and late stages, Alzheimer's disease, Multiple sclerosis, coronary artery disease has been substantiated using both experimental models and clinical studies. TNF also plays a key role in cardiovascular disease, initiating a cascade of inflammatory and vascular responses. The aim of this study is to clarify the molecular mechanisms of TNF action and the effects of its secretion in selected diseases.<\/jats:p>","DOI":"10.5114\/aoms\/201446","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T21:36:16Z","timestamp":1745184976000},"source":"Crossref","is-referenced-by-count":1,"title":["The Importance of TNF-\u03b1 Signaling \u2013 Potential Risk Factor in Neurodegenerative and Cardiovascular Diseases"],"prefix":"10.5114","author":[{"given":"Bia\u0142ecka","family":"Marta","sequence":"first","affiliation":[{"name":"Military Medical National Research Institute, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Bia\u0142ecka","sequence":"additional","affiliation":[{"name":"Pomeranian Medical University, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Machoy-Mokrzy\u0144ska","sequence":"additional","affiliation":[{"name":"Pomeranian Medical University, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Malinowski","sequence":"additional","affiliation":[{"name":"Pomeranian Medical University, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Ra\u0107","sequence":"additional","affiliation":[{"name":"Pomeranian Medical University, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2025,4,20]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-201446-124637","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-201446-124637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T21:36:16Z","timestamp":1745184976000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/The-Importance-of-TNF-Signaling-Potential-Risk-Factor-in-Neurodegenerative-and-Cardiovascular,201446,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,20]]},"references-count":0,"alternative-id":["201446"],"URL":"https:\/\/doi.org\/10.5114\/aoms\/201446","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,20]]}}}