{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T07:49:34Z","timestamp":1775202574397,"version":"3.50.1"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Urological cancers pose a significant global health burden. Alterations in immunoglobulin G(IgG) N-glycosylation are implicated in cancer pathogenesis, but their causal role remains unclear. This study aimed to explore the potential causal associations between 77 specific IgG N-glycan traits (IGPs) and the risks of bladder, kidney, and prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>We conducted a two-sample Mendelian randomization (MR) study using summary-level data. Genetic instruments for IGPs were obtained from a genome-wide association study (GWAS) of European descent. Outcome data were sourced from the FinnGen consortium. The inverse-variance weighted (IVW) method was the primary analysis, supplemented by multiple sensitivity analyses (MR-Egger, weighted median, MR-PRESSO, and MR-RAPS). The Steiger test was used to confirm causal direction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After a strict false discovery rate (FDR) correction, one association remained statistically significant. Using the IVW method, genetically predicted higher levels of IGP23 were significantly associated with a decreased risk of bladder cancer (OR = 0.78, P = 4.7e-04, FDR = 0.037). Thirteen other nominal associations (P &lt; 0.05) were also identified, suggesting potential risk or protective factors for urological cancers (e.g., IGP10 for prostate cancer; IGP52, IGP73 for kidney cancer), although these did not withstand multiple testing correction. Sensitivity analyses indicated no significant directional pleiotropy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study provides robust genetic evidence for a causal protective effect of the IgG N-glycan trait IGP23 on the risk of bladder cancer. While other nominal associations require further investigation, our findings highlight IGP23 as a key candidate for future mechanistic research and potential biomarker development in bladder cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5114\/aoms\/214288","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:39:51Z","timestamp":1775194791000},"source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Causal Role of IgG N-Glycosylation in Urological Cancers: A Two-Sample Mendelian Randomization Study Using European Ancestry Datasets"],"prefix":"10.5114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7478-7529","authenticated-orcid":false,"given":"Yatfaat","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Urology, Suzhou BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Suzhou, 215000, Jiangsu, China, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7895-4626","authenticated-orcid":true,"given":"Manchun","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Suzhou BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Suzhou, 215000, Jiangsu, China, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2026,4,3]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-214288-138224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-214288-138224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:39:54Z","timestamp":1775194794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Exploring-the-Causal-Role-of-IgG-N-Glycosylation-in-Urological-Cancers-A-Two-Sample,214288,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,3]]},"references-count":0,"alternative-id":["214288"],"URL":"https:\/\/doi.org\/10.5114\/aoms\/214288","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,3]]}}}