{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T07:49:29Z","timestamp":1775202569791,"version":"3.50.1"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"abstract":"<jats:p>Cholesterol is an essential lipid for cellular integrity and metabolic homeostasis; however, dysregulated cholesterol metabolism is increasingly recognized as a key contributor to multiple ocular diseases. Beyond its established role in cardiovascular pathology, emerging evidence implicates altered lipoprotein balance, impaired cholesterol transport, and lipid-driven inflammation in the pathogenesis of age-related macular degeneration, retinal vascular diseases, cataracts, and glaucoma. This review integrates current knowledge on cholesterol synthesis, transport, and regulation with ocular-specific mechanisms, emphasizing the differential roles of low-density lipoprotein, high-density lipoprotein, and triglyceride-rich lipoproteins. Key molecular pathways, including the mevalonate-SREBP axis, ABCA1\/ABCG1-mediated reverse cholesterol transport, VEGF-driven angiogenesis, oxidative stress signaling, and inflammatory cascades, are critically discussed. Clinical and translational implications are highlighted, particularly the potential ocular benefits of lipid-modulating therapies such as statins, fenofibrate, and antioxidant supplementation. Understanding cholesterol as a modifiable determinant of ocular health may enable integrated preventive strategies and guide future therapeutic innovation in vision-threatening diseases.<\/jats:p>","DOI":"10.5114\/aoms\/216374","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:39:51Z","timestamp":1775194791000},"source":"Crossref","is-referenced-by-count":0,"title":["Understanding The Link Between Lipid and Ocular Disorders for Effective Therapy"],"prefix":"10.5114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1216-8217","authenticated-orcid":true,"given":"Muhammad Zulfiqah","family":"Sadikan","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9614-6650","authenticated-orcid":true,"given":"Haryati","family":"Ahmad Hairi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Manipal University College Malaysia, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9825-7995","authenticated-orcid":true,"given":"Lidawani","family":"Lambuk","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2026,4,3]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-216374-138230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-216374-138230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:39:52Z","timestamp":1775194792000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Understanding-The-Link-Between-Lipid-and-Ocular-Disorders-for-Effective-Therapy,216374,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,3]]},"references-count":0,"alternative-id":["216374"],"URL":"https:\/\/doi.org\/10.5114\/aoms\/216374","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,3]]}}}