{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:16:53Z","timestamp":1783505813565,"version":"3.55.0"},"reference-count":50,"publisher":"Termedia Sp. z.o.o.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Updated estimates of the current and future burden of non-Hodgkin lymphoma (NHL) are critical for evaluating global cancer control efforts and addressing disparities in disease impact across regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>We assessed the 2022 global NHL burden and projected trends to 2045 across 185 countries using population-based cancer registry data from the Cancer Incidence in Five Continents (CI5) database and GLOBOCAN 2022 estimates. Trends in age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) from 1990 to 2017\/2020 were analyzed in selected regions to contextualize findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2022, an estimated 553,389 new NHL cases (ASIR 5.6\/100,000) and 250,679 deaths (ASMR 2.4\/100,000) occurred globally. The highest case numbers were observed at ages 65\u201369, with ASIR peaking at 85+ and men consistently showing higher rates. High-HDI regions, such as Northern America (ASIR 12.49) and Australia\/New Zealand (ASIR 12.05), reported elevated incidence compared to low-HDI regions like South-Central Asia (ASIR 2.79). East Asia, led by China (14.6% of cases), had the largest case volume. ASIR strongly correlated with HDI (r = 0.655, p = 3.21E-22), while ASMR showed no significant correlation (r = 0.002, p = 0.982). By 2045, NHL cases are projected to increase to 889,841 and deaths to 433,254, with low-HDI regions experiencing the steepest rises.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings reveal pronounced global disparities in NHL burden, with high-HDI regions benefiting from treatment advances, while low-HDI areas face escalating challenges by 2045. Addressing aging-driven incidence, expanding diagnostic capacity in resource-limited settings, and strengthening prevention efforts are imperative to tackle these inequities and curb the projected burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5114\/aoms\/218811","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T09:38:16Z","timestamp":1783503496000},"page":"1312-1325","source":"Crossref","is-referenced-by-count":0,"title":["The global landscape of non-Hodgkin lymphoma incidence and mortality in 2022 and projections to 2045"],"prefix":"10.5114","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-379X","authenticated-orcid":false,"given":"Zhixing","family":"Kuang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Nanping First Hospital affiliated to Fujian Medical University, Nanping, Fujian, China"},{"name":"Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0023-3520","authenticated-orcid":true,"given":"Lingling","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Southern University of Sciences and Technology Yantian Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5627-1336","authenticated-orcid":true,"given":"Lilin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Emergency, Longgang District Central Hospital of Shenzhen, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2611-9734","authenticated-orcid":true,"given":"Rongqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Nanping First Hospital affiliated to Fujian Medical University, Nanping, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0116-1700","authenticated-orcid":true,"given":"Xinfei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Nanping First Hospital affiliated to Fujian Medical University, Nanping, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4160-1781","authenticated-orcid":true,"given":"Aihua","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Nanping First Hospital affiliated to Fujian Medical University, Nanping, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9706-9961","authenticated-orcid":true,"given":"Jiannan","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Xiamen Cancer Hospital, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"ref-1921446","doi-asserted-by":"crossref","unstructured":"Luo J, Craver A, Bahl K, et al. 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