{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:24:15Z","timestamp":1787304255756,"version":"build-2736575974"},"reference-count":18,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"DOI":"10.5114\/aoms\/226402","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:31:57Z","timestamp":1787301117000},"source":"Crossref","is-referenced-by-count":0,"title":["Synchronous myelodysplastic syndrome and multiple myeloma: a DDX41-associated double-hit across two lineages"],"prefix":"10.5114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4497-8479","authenticated-orcid":false,"given":"Lihong","family":"Wang","sequence":"first","affiliation":[{"name":"Anqing Municipal Hospital, Anqing Hospital Affiliated to China Pharmaceutical University, Anqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0521-5742","authenticated-orcid":true,"given":"Hong","family":"Yan","sequence":"additional","affiliation":[{"name":"Anqing Municipal Hospital, Anqing Hospital Affiliated to China Pharmaceutical University, Anqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6113-1000","authenticated-orcid":true,"given":"Long","family":"Zhong","sequence":"additional","affiliation":[{"name":"Anqing Municipal Hospital, Anqing Hospital Affiliated to China Pharmaceutical University, Anqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0977-6430","authenticated-orcid":true,"given":"Haitao","family":"Xu","sequence":"additional","affiliation":[{"name":"Anqing Municipal Hospital, Anqing Hospital Affiliated to China Pharmaceutical University, Anqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5618-0679","authenticated-orcid":true,"given":"Dangui","family":"Chen","sequence":"additional","affiliation":[{"name":"Anqing Municipal Hospital, Anqing Hospital Affiliated to China Pharmaceutical University, Anqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"ref-1966289","doi-asserted-by":"crossref","unstructured":"Washington NR, Shippey EA, Osswald M. Successful treatment of concurrently diagnosed multiple myeloma and myelodysplastic syndrome with isolated Del(5q) with lenalidomide, bortezomib, and dexamethasone. Cureus 2021; 13: e19742.","DOI":"10.7759\/cureus.19742"},{"key":"ref-1966290","doi-asserted-by":"crossref","unstructured":"Jonsdottir G, Bj\u00f6rkholm M, Turesson I, et al. Cumulative exposure to melphalan chemotherapy and subsequent risk of developing acute myeloid leukemia and myelodysplastic syndromes in patients with multiple myeloma. Eur J Haematol 2021; 107: 275-82.","DOI":"10.1111\/ejh.13650"},{"key":"ref-1966291","doi-asserted-by":"crossref","unstructured":"Yalniz FF, Greenbaum U, Pasvolsky O, et al. Characteristics and outcomes of patients with multiple myeloma who developed therapy-related acute myeloid leukemia and myelodysplastic syndrome after autologous cell transplantation. Transplant Cell Ther 2024; 30: 205.e201-12.","DOI":"10.1016\/j.jtct.2023.06.015"},{"key":"ref-1966292","doi-asserted-by":"crossref","unstructured":"Chlon TM, Stepanchick E, Hershberger CE, et al. Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia. Cell Stem Cell 2021; 28: 1966-81.","DOI":"10.1016\/j.stem.2021.08.004"},{"key":"ref-1966293","doi-asserted-by":"crossref","unstructured":"Winstone L, Jung Y, Wu Y. DDX41: exploring the roles of a versatile helicase. Biochem Soc Trans 2024; 52: 395-405.","DOI":"10.1042\/BST20230725"},{"key":"ref-1966294","doi-asserted-by":"crossref","unstructured":"Weinreb JT, Bowman TV. Clinical and mechanistic insights into the roles of DDX41 in haematological malignancies. FEBS Lett 2022; 596: 2736-45.","DOI":"10.1002\/1873-3468.14487"},{"key":"ref-1966295","doi-asserted-by":"crossref","unstructured":"Stepanchick E, Wilson A, Sulentic AM, et al. DDX41 haploinsufficiency causes inefficient hematopoiesis under stress and cooperates with p53 mutations to cause hematologic malignancy. Leukemia 2024; 38: 1787-98.","DOI":"10.1038\/s41375-024-02304-9"},{"key":"ref-1966296","doi-asserted-by":"crossref","unstructured":"Miao L, Wang X, Yao M, Tao Y, Han Y. Clinicopathological and prognostic significance of DDX41 mutation in myeloid neoplasms: a systematic review and meta-analysis. Ann Hematol 2025; 104: 2581-91.","DOI":"10.1007\/s00277-025-06278-1"},{"key":"ref-1966297","doi-asserted-by":"crossref","unstructured":"Tiong IS, Stevenson WS, Wall M, et al. Favorable outcomes of DDX41-mutated myelodysplastic syndrome and low blast count acute myeloid leukemia treated with azacitidine \u00b1 lenalidomide. EJHaem 2023; 4: 1212-5.","DOI":"10.1002\/jha2.767"},{"key":"ref-1966298","doi-asserted-by":"crossref","unstructured":"Goyal T, Tu ZJ, Wang Z, Cook JR. Clinical and pathologic spectrum of DDX41-mutated hematolymphoid neoplasms. Am J Clin Pathol 2021; 156: 829-38.","DOI":"10.1093\/ajcp\/aqab027"},{"key":"ref-1966299","doi-asserted-by":"crossref","unstructured":"Makishima H, Saiki R, Nannya Y, et al. Germ line DDX41 mutations define a unique subtype of myeloid neoplasms. Blood 2023; 141: 534-49.","DOI":"10.1182\/blood.2022018221"},{"key":"ref-1966300","doi-asserted-by":"crossref","unstructured":"Bataller A, Loghavi S, Gerstein Y, et al. Characteristics and clinical outcomes of patients with myeloid malignancies and DDX41 variants. Am J Hematol 2023; 98: 1780-90.","DOI":"10.1002\/ajh.27070"},{"key":"ref-1966301","doi-asserted-by":"crossref","unstructured":"Alkhateeb HB, Nanaa A, Viswanatha D, et al. Genetic features and clinical outcomes of patients with isolated and comutated DDX41-mutated myeloid neoplasms. Blood Adv 2022; 6: 528-32.","DOI":"10.1182\/bloodadvances.2021005738"},{"key":"ref-1966302","doi-asserted-by":"crossref","unstructured":"Bruehl FK, Elbaz Younes I, Bosler DS, Kelemen K, Jiang L, Reichard KK. Peripheral blood and bone marrow findings in treatment-naive patients with cytopenia(s)\/myeloid neoplasms harboring both a germline and a somatic DDX41 mutation. Appl Immunohistochem Mol Morphol 2024; 32: 371-81.","DOI":"10.1097\/PAI.0000000000001215"},{"key":"ref-1966303","doi-asserted-by":"crossref","unstructured":"Yan W, Qu XY, Li H, et al. Coexistence of plasma cell neoplasia and myelodysplastic syndrome with excess blasts: case reports and literature review. Ann Palliat Med 2021; 10: 12431-40.","DOI":"10.21037\/apm-21-3210"},{"key":"ref-1966304","doi-asserted-by":"crossref","unstructured":"Li P, Brown S, Williams M, et al. The genetic landscape of germline DDX41 variants predisposing to myeloid neoplasms. Blood 2022; 140: 716-55.","DOI":"10.1182\/blood.2021015135"},{"key":"ref-1966305","doi-asserted-by":"crossref","unstructured":"Yasuda T, Sanada M, Nishijima D, et al. Clinical utility of target capture-based panel sequencing in hematological malignancies: a multicenter feasibility study. Cancer Sci 2020; 111: 3367-78.","DOI":"10.1111\/cas.14552"},{"key":"ref-1966306","doi-asserted-by":"crossref","unstructured":"Liu J, Tang Y, Qin T, et al. The dynamic alterations of DDX41 mutations in patients with myelodysplastic neoplasms treated with lenalidomide. Leuk Lymphoma 2026; 67: 699-703.","DOI":"10.1080\/10428194.2025.2582715"}],"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-226402-143565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-226402-143565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:32:01Z","timestamp":1787301121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Synchronous-myelodysplastic-syndrome-and-multiple-myeloma-a-DDX41-associated-double,226402,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":18,"alternative-id":["226402"],"URL":"https:\/\/doi.org\/10.5114\/aoms\/226402","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]}}}