{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:44:37Z","timestamp":1788327877601,"version":"build-2803163510"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2019,9,9]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Acute appendicitis (AA) is the most common surgical condition of the abdomen in children. The aim of this study was to analyse the possible use of the neutrophil-to-lymphocyte ratio (NLR) in the diagnosis and prediction of AA complications in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We included 170 AA patients under 15 years of age, who were divided into the following groups: Group 1 \u2013 non-operated patients with AA, and Group 2 \u2013 patients who underwent appendectomy. Based on pathologic grades of AA, Group 2 was subdivided into: Group A \u2013 phlegmonous, Group B \u2013 gangrenous, and Group C \u2013 perforated AA. NLR was calculated as the absolute neutrophil count divided by the absolute lymphocyte count.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In Group 2 NLR was significantly higher than in Group 1 (5.5 [1.9\u20139.9] vs. 2.3 [1.2\u20133.7]; p &lt; 0.001). A significant difference in NLR was found between Group C and Group A (p &lt; 0.001), and as well as between Group B and Group A (p = 0.001). The determined optimal cut-off value of NLR in differentiating Group 1 vs. Group 2 was \u2265 3.48 (p &lt; 0.001). In differentiating Group A from Group C the optimal cut-off value of NLR was \u2265 5.61 (p &lt; 0.001). Furthermore, optimal cut-off value of NLR in differentiating Group A from Group B was \u2265 5.45 (p = 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The obtained results suggest that NLR could be used as a simple and reliable test in the diagnosis and prediction of AA complications in children. However, to draw definite conclusions on the predictive power of NLR as a marker of AA large multicentric studies are required.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms.2019.87697","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T08:55:31Z","timestamp":1568019331000},"source":"Crossref","is-referenced-by-count":7,"title":["Could the neutrophil-to-lymphocyte ratio serve as a marker in the diagnosis and prediction of acute appendicitis complications in children?"],"prefix":"10.5114","author":[{"given":"Sadeta","family":"Begic-Kapetanovic","sequence":"first","affiliation":[{"name":"Clinic of Pediatric Surgery, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesina","family":"Avdagic","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, Faculty of Medicine University of Sarajevo, Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asija","family":"Zaciragic","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, Faculty of Medicine University of Sarajevo, Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabaheta","family":"Hasic","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine University of Sarajevo, Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermina","family":"Babic","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, Faculty of Medicine University of Sarajevo, Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Hadzimuratovic","sequence":"additional","affiliation":[{"name":"Clinic of Surgery Karabeg, Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2019,9,9]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-99612-59785","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-99612-59785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T08:45:15Z","timestamp":1619685915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Could-the-neutrophil-to-lymphocyte-ratio-serve-as-a-marker-in-the-diagnosis-and-prediction,99612,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,9]]},"references-count":0,"alternative-id":["99612"],"URL":"https:\/\/doi.org\/10.5114\/aoms.2019.87697","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,9]]}}}