{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T18:12:21Z","timestamp":1762020741819,"version":"build-2065373602"},"reference-count":29,"publisher":"Termedia Sp. z.o.o.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Testicular cancer (TC) is the most frequent cancer among men aged 14\u201344 years. The risk of erectile dysfunction (ED) in TC patients varied within a wide range across different studies. This study aims to estimate the risk of ED in TC patients by conducting a meta-analysis of case-control studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Relevant studies were searched using PubMed, EMBASE, Scopus, and the Cochrane Library up to June 2019. Case-control studies that reported the incidence of ED in TC patients were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 8 studies involving 2060 TC patients and 2651 healthy men were included. All the TC patients underwent unilateral orchiectomy; other treatment modalities were also conducted if necessary. ED occurred in 16.9% (348\/2060) of TC patients and 9.4% (251\/2651) of healthy men. Compared with healthy men, TC patients experienced a significantly increased risk of ED (OR = 2.39, 95% CI: 1.56\u20133.67). Substantial heterogeneity was observed. In addition, subgroup analysis revealed that the risk (OR = 3.76, 95% CI: 2.45\u20135.78) for ED in TC patients with follow-up &lt; 5 years was significantly higher than that (OR = 1.61, 95% CI: 1.10\u20133.67) with follow-up \u2265 5 years. Heterogeneity was improved after subgroup analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TC patients experienced an increased risk for ED compared with healthy men. The long-term risk for ED in TC patients was lower than the short-term risk.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms.2020.92297","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T22:02:16Z","timestamp":1580508136000},"page":"822-830","source":"Crossref","is-referenced-by-count":2,"title":["Erectile dysfunction in testicular cancer survivors: a meta-analysis of case-control studies"],"prefix":"10.5114","volume":"20","author":[{"given":"Jian","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Dongcheng District, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Dongcheng District, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonglin","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Dongcheng District, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengquan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Dongcheng District, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Dongcheng District, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2020,1,15]]},"reference":[{"key":"ref-1216930","doi-asserted-by":"crossref","unstructured":"Aparicio J, Terrasa J, Dur\u00e1n I, et al. 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