{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:47:16Z","timestamp":1767847636166,"version":"3.49.0"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2020,1,29]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>High estrogen levels could reduce pregnancy rates by disrupting the\u00a0implantation of\u00a0the\u00a0embryo into the\u00a0endometrium in patients treated with fresh cycles of\u00a0in vitro fertilization. The\u00a0aim of\u00a0the\u00a0present study was to investigate the\u00a0effect of\u00a0estrogen levels on the\u00a0pregnancy and abortion rate in autologous frozen embryo transfer with hormone replacement therapy (HRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A\u00a0historical cohort study was conducted in an\u00a0academic setting to investigate the\u00a0effect of\u00a0estrogen levels on the\u00a0pregnancy and abortion rates for all autologous artificial frozen embryo transfer cycles performed from January 2016 to January 2018. Serum estradiol levels recorded on day 2 or 3 of\u00a0the\u00a0cycle were stated as e1, and levels recorded on the\u00a0day of\u00a0progesterone were indicated as e2. Human chorionic gonadotropin (\u03b2-hCG) positivity, which was examined 14 days after the\u00a0transfer, was used to evaluate biochemical pregnancy. Abortion was defined as the\u00a0termination of\u00a0pregnancy before the\u00a020th gestational week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 130 patients with unexplained infertility, 20 patients with poor ovarian reserve, and 54 patients with male factor. Of the\u00a0patients with unexplained infertility, poor ovarian reserve, and male factor, 58, 4, and 27 of\u00a0them were pregnant, respectively. No statistically significant difference was found between the\u00a0e1 and e2 levels of\u00a0the\u00a0pregnant and non-pregnant groups (p\u00a0=\u00a00.273, p\u00a0=\u00a00.219). In addition, there was no statistically significant difference between e2 levels in terms of\u00a0the\u00a0abortion rate (p\u00a0=\u00a00.722).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In autologous frozen embryo transfer with HRT, estrogen levels did not have a\u00a0significant effect on the\u00a0pregnancy or abortion rate. Therefore, estrogen levels do not need to be monitored in frozen embryo transfer with HRT.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms.2020.92466","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T22:02:16Z","timestamp":1580508136000},"source":"Crossref","is-referenced-by-count":6,"title":["Does high estrogen level negatively affect pregnancy success in frozen embryo transfer?"],"prefix":"10.5114","author":[{"given":"Ay\u015fe","family":"\u00d6zdemir","sequence":"first","affiliation":[{"name":"Ondokuz Mayis University, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pervin","family":"Karli","sequence":"additional","affiliation":[{"name":"Amasya Un\u0131vers\u0131ty, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7a\u011fr\u0131","family":"G\u00fcl\u00fcmser","sequence":"additional","affiliation":[{"name":"Ba\u015fkent Un\u0131versity, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2020,1,29]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-109372-59706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-109372-59706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T14:22:50Z","timestamp":1635517370000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Does-high-estrogen-level-negatively-affect-pregnancy-success-in-frozen-embryo-transfer,109372,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,29]]},"references-count":0,"alternative-id":["109372"],"URL":"https:\/\/doi.org\/10.5114\/aoms.2020.92466","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,29]]}}}