{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:17:02Z","timestamp":1782209822549,"version":"3.54.5"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2020,7,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Osteoarthritis (OA) is the most common degenerative joint disease, and its aetiology is not entirely known. The aim of the study was to evaluate the involvement of interleukin-18 (IL-18) and interleukin-20 (IL-20) in the pathogenesis of knee OA and their correlations with other markers of inflammation and destruction of joint cartilage, as well as clinical and radiological changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The study included 25 patients with knee OA and a control group. The concentration of IL-18, IL-20, IL-6, MMP-1, MMP-3, COMP, PG-AG, and YKL-40 in serum and synovial fluid (SF) were determined. We also evaluated radiological lesions of the knee joint according to the Kellgren-Lawrence (K-L) scale, and clinical severity of the disease according to Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Lequesne Index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The concentrations of IL-18 and IL-20 were statistically significantly higher in serum of patients with OA than in the control group (106.00 \u00b1189.76 pg\/ml vs. 16.73 \u00b116.99 pg\/ml, p &lt; 0.001, 17.69 \u00b113.45 pg\/ml vs. 9.76 \u00b19.00 pg\/ml, p &lt; 0.014). Serum concentration of IL-18 positively correlated with MMP-3 (R = 0.58; p = 0.006) and YKL-40 (R = 0.48; p = 0.002). The degree of radiological advancement of OA (K-L scale) correlated positively with clinical evaluation (WOMAC, R = 0.74, p \u2264 0.001; Lequesne Index, R = 0.57, p = 0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The analysis of ROC curves showed that IL-20 as well as COMP, MMP-3, and YKL-40 may be diagnostic markers of knee OA. The observations indicate that IL-18 potentially mediates mainly in intra-articular processes and IL-20 could be primarily responsible for the systemic inflammatory reaction.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms.2020.96717","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T13:32:42Z","timestamp":1594733562000},"source":"Crossref","is-referenced-by-count":7,"title":["Serum and synovial fluid concentrations of interleukin-18 and interleukin-20 in patients with osteoarthritis of the knee and their correlation with other markers of inflammation and turnover of joint cartilage"],"prefix":"10.5114","author":[{"given":"Micha\u0142","family":"Waszczykowski","sequence":"first","affiliation":[{"name":"Department of Arthroscopy, Minimally Invasive Surgery, and Sports Traumatology, Medical University of Lodz, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Fabi\u015b-Strobin","sequence":"additional","affiliation":[{"name":"Clinic of Orthopaedic and Traumatology, Polish Mother\u2019s Memorial Hospital Research Institute, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Bednarski","sequence":"additional","affiliation":[{"name":"Dermatology, Paediatric Dermatology, and Oncology Clinic, Medical University of Lodz, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Narbutt","sequence":"additional","affiliation":[{"name":"Dermatology, Paediatric Dermatology, and Oncology Clinic, Medical University of Lodz, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Fabi\u015b","sequence":"additional","affiliation":[{"name":"Department of Arthroscopy, Minimally Invasive Surgery, and Sports Traumatology, Medical University of Lodz, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2020,7,3]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-122730-59580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-122730-59580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T14:18:04Z","timestamp":1635517084000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Serum-and-synovial-fluid-concentrations-of-interleukin-18-and-interleukin-20-in-patients,122730,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,3]]},"references-count":0,"alternative-id":["122730"],"URL":"https:\/\/doi.org\/10.5114\/aoms.2020.96717","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,3]]}}}