{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T23:58:07Z","timestamp":1649203087743},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2020,8,6]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Warty carcinoma (WC) of the uterine cervix is a rare subtype of squamous-cell carcinoma (SCC), and its frequency, clinical behaviour, and aetiology are obscure. It originates from condylomas, and a viral carcinogenesis seems logical.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Retrospective analysis was performed of all cervical carcinomas (CC), diagnosed at a single institution for a 10-year period. Analysed patients had stage I carcinoma. Patients with WC were identified, and their tumour samples were tested for high-risk HPV (hr-HPV) and EBV, using PCR and ISH. Clinical characteristics and WC rates across all stage I CC patients were assessed. All patients had minimum 3-year follow-up, and overall survival (OS) and 5-year survival rates were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>WC comprised 2.2% of all stage I CC (n = 630). The mean age of the patients was 48 years (range: 29\u201372). The primary tumour size was 2 cm in 4 (28.6%) patients, 2\u20134 cm in 2 (14.3%) patients, and 4 cm in 8 (57.1%) patients. Lymph node metastasis was found in 1 (7.1%) patient. EBV or hr-HPV were detected in 2 (18.2%) patients using ISH, with no coinfection reported. Hr-HPV was detected in 2 (18.2%) patients; EBV in 4 (36.4%) cases, and in 2 of them (18.2%) there was a co-infection. Thirteen patients had a follow-up of \u2265 5 years and their 5-year OS was 100%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>WC is a rare subtype of SCC with good prognosis, regardless of viral status. In contrast to SCC, its aetiology is not related to hr-HPV. The role of EBV remains unclear and cannot currently be denied.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms.2020.97997","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T07:47:52Z","timestamp":1598428072000},"source":"Crossref","is-referenced-by-count":0,"title":["Warty carcinoma of the uterine cervix: a virus-induced disease?"],"prefix":"10.5114","author":[{"given":"Angel","family":"Yordanov","sequence":"first","affiliation":[{"name":"Department of Gynaecological Oncology, Medical University Pleven, Pleven, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Department of General and Clinical Pathology, Medical University Pleven, Pleven, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tereza","family":"Dineva","sequence":"additional","affiliation":[{"name":"Scientific Laboratory, Department of Epidemiology, Medical University Pleven, Pleven, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislav","family":"Slavchev","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Medical University Varna, Varna, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stoyan","family":"Kostov","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Medical University Varna, Varna, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Strahil","family":"Strashilov","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, MU-Pleven, Pleven, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assia","family":"Konsoulova","sequence":"additional","affiliation":[{"name":"Complex Oncological Centre Burgas, Burgas, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2020,8,6]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-124976-59552","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-124976-59552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T14:17:23Z","timestamp":1635517043000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Warty-carcinoma-of-the-uterine-cervix-a-virus-induced-disease-,124976,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":0,"alternative-id":["124976"],"URL":"https:\/\/doi.org\/10.5114\/aoms.2020.97997","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,6]]}}}