{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T16:26:20Z","timestamp":1769012780169,"version":"3.49.0"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2020,8,20]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Bacterial community-acquired pneumonia (CAP) in children is caused mostly by Streptococcus pneumoniae. The resistance of pneumococci to penicillin is increasing. However, most guidelines still prefer treatment with narrow-spectrum antibiotics. Therefore, we compared the effect of intravenous treatment with penicillin and broad-spectrum \u03b2-lactam antibiotics in children with CAP. The objective of our study was to assess the eligibility of treatment of bacterial CAP with intravenous penicillin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We performed a prospective study and included 136 children hospitalised because of bacterial CAP. Patients were treated intravenously with either penicillin G or broad-spectrum \u03b2-lactam antibiotic monotherapy. Lung ultrasound and blood tests were performed at admission and after 2 days of treatment. The time interval from the application of antibiotics to permanent defervescence was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty-seven (64.0%) patients were treated with penicillin G, and 49 (36.0%) were treated with broad-spectrum \u03b2-lactam antibiotics. The median time to persistent defervescence was 5 h in the penicillin group and 8 h in the broad-spectrum group (p = 0.18). There were no significant differences between the treatment regimens regarding the effect on the consolidation sizes or C-reactive protein levels. However, the decrease in the white blood cell count was marginally greater in the penicillin treatment group (p = 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have shown that penicillin is as effective as broad-spectrum antibiotics in the treatment of bacterial CAP in children. Although the resistance of pneumococci to antibiotics is increasing, clinicians should still use penicillin and other narrow-spectrum \u03b2-lactam antibiotics in the treatment of bacterial CAP in children.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms.2020.98198","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T07:47:52Z","timestamp":1598428072000},"source":"Crossref","is-referenced-by-count":1,"title":["Comparison of the effectiveness of penicillin and broad-spectrum \u03b2-lactam antibiotics in the treatment of community-acquired pneumonia in children"],"prefix":"10.5114","author":[{"given":"Vojko","family":"Berce","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University Medical Centre, Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Tomazin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Medical Centre, Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Jerele","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, University of Maribor, Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0161a","family":"Cugmas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, University of Maribor, Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0161a","family":"Berce","sequence":"additional","affiliation":[{"name":"Section of Dental Medicine, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Gorenjak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, University of Maribor, Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2020,8,20]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-125422-59541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-125422-59541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T14:17:07Z","timestamp":1635517027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/Comparison-of-the-effectiveness-of-penicillin-and-broad-spectrum-lactam-antibiotics,125422,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,20]]},"references-count":0,"alternative-id":["125422"],"URL":"https:\/\/doi.org\/10.5114\/aoms.2020.98198","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,20]]}}}