{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T07:43:32Z","timestamp":1707896612683},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci"],"published-print":{"date-parts":[[2024,1,31]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>This prospective randomized controlled trial aimed to evaluate the effect of intrauterine insemination (IUI) before frozen-thawed elective single embryo transfer (FT-eSET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A total of 200 couples with unexplained subfertility underwent in-vitro fertilization (IVF) treatment. Patients were randomly assigned to either FT-eSET or IUI preceding FT-eSET. Both groups were composed of 100 women. IUI was timed 6 days before FT-eSET in the IUI preceding FT-eSET group. Implantation rates (IR), biochemical and clinical abortion rates (AR), clinical pregnancy rates (PR), ongoing pregnancy rates (PRs), and live birth rates were measured in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IUI preceding FT-eSET group was associated with higher rates of clinical pregnancy, 54% vs. 42%, but not significantly. Similarly, IR, PR and live birth rate were higher in the IUI preceding FT-eSET group but not significantly. In the IUI preceding FT-eSET group, the biochemical and clinical abortion rates were lower than in the control group (9.5% vs. 14.2% and 5.5% vs. 5.2%, respectively). However, no statistically significant difference was found between the two groups, either.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study showing that IUI may precede FT-eSET to improve PR in couples with unexplained subfertility. Also, performing IUI before FT-eSET may decrease biochemical and clinical abortion rates.<\/jats:p><\/jats:sec>","DOI":"10.5114\/aoms.2020.98412","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T08:29:05Z","timestamp":1600244945000},"page":"81-85","source":"Crossref","is-referenced-by-count":0,"title":["The effect of intrauterine insemination preceding frozen-thawed elective single embryo transfer in couples with unexplained subfertility"],"prefix":"10.5114","volume":"20","author":[{"given":"Gokalp","family":"Oner","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Acibadem Hospital, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu","family":"Ciftci","sequence":"additional","affiliation":[{"name":"Bahcesehir University, School of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurettin","family":"Turktekin","sequence":"additional","affiliation":[{"name":"Istanbul IVF Center, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Tas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Acibadem Hospital, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasa","family":"Ulug","sequence":"additional","affiliation":[{"name":"Erzincan University, School of Medicine, Erzincan, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakup","family":"Kumtepe","sequence":"additional","affiliation":[{"name":"Erzurum University, School of Medicine, Erzurum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2020,8,25]]},"container-title":["Archives of Medical Science"],"original-title":[],"link":[{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-122733-104753","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.archivesofmedicalscience.com\/pdf-122733-104753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T07:09:56Z","timestamp":1707894596000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.archivesofmedicalscience.com\/The-effect-of-intrauterine-insemination-preceding-frozen-thawed-elective-single-embryo,122733,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,25]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"alternative-id":["122733"],"URL":"https:\/\/doi.org\/10.5114\/aoms.2020.98412","relation":{},"ISSN":["1734-1922","1896-9151"],"issn-type":[{"value":"1734-1922","type":"print"},{"value":"1896-9151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,25]]}}}