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After irradiation, biochemical parameters, immunohistochemical, and histological examinations were conducted on the ileum of the mice. IR exposure increased the levels of malondialdehyde and protein carbonyl, while glutathione levels, as oxidative stress biomarkers, decreased. Apoptosis in ileum tissues was also assessed. Furthermore, histopathological changes were observed in the irradiated mice. GLZ treatment significantly mitigated these changes. The administration of GLZ resulted in a marked decrease in caspase-3 immunoreactivity in the ileum of irradiated mice. This preclinical study exhibited that GLZ has a radioprotective effect against intestinal injury by inhibiting oxidative stress and apoptosis.<\/jats:p>","DOI":"10.5114\/bta.2024.145257","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T07:17:19Z","timestamp":1734592639000},"page":"367-376","source":"Crossref","is-referenced-by-count":4,"title":["Gliclazide protects ionizing radiation-induced intestinal injury\nin mice by inhibiting oxidative stress and caspase-3"],"prefix":"10.5114","volume":"105","author":[{"given":"Soroush","family":"Arzani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soghra","family":"Farzipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh Talebpour","family":"Amiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Jalal","family":"Hosseinimehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"ref-1360445","doi-asserted-by":"crossref","first-page":"110134","DOI":"10.1016\/j.biopha.2020.110134","article-title":"X irradiation induced colonic mucosal injury and the detection of apoptosis through PARP-1\/p53 regulatory pathway","volume":"127","author":"Akpolat M","year":"2020","unstructured":"Akpolat M., Oz Z.S., Gulle K., Hamamcioglu A., Bakkal B.H., Kececi M. 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