{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:01:36Z","timestamp":1784019696426,"version":"3.55.0"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","issue":"3","license":[{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cent Eur J Immunol"],"abstract":"<jats:p>Elastase and metalloproteinase-9 (MMP-9) are two of numerous proteolytic enzymes released by neutrophilic granulocytes in the course of periodontitis. The aim of the study was to determine the concentrations of elastase and MMP-9 in saliva in patients with chronic periodontitis compared to healthy individuals.&lt;br \/&gt;\nThe enzyme-linked immunosorbent assay method was employed to determine the concentrations of elastase and MMP-9 in saliva in patients with chronic periodontitis and with pocket depth (PD) \u2265 6 mm and PD &lt; 6 mm, as well as in saliva of healthy individuals. Significantly higher concentrations of elastase and MMP-9 were observed in patients with periodontitis compared to healthy individuals (p &lt; 0.01). Also a significant difference in elastase concentration in saliva was observed between the PD \u2265 4 mm and PD &lt; 6 mm groups and between the PD \u2265 6 mm and control groups, and statistically significant differences in MMP-9 concentrations between the PD \u2265 6 mm and control groups. No statistically significant differences were observed between the PD &lt; 6 mm and control groups for elastase concentrations in saliva as well as between the PD \u2265 6 mm and PD &lt; 6 mm groups, and also between the PD &lt; 6 mm and control groups for MMP-9 concentrations in saliva. Elastase and MMP-9 concentrations in saliva can be considered as biochemical indicators of severity of periodontitis.<\/jats:p>","DOI":"10.5114\/ceji.2014.45948","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T09:27:14Z","timestamp":1415784434000},"page":"357-364","source":"Crossref","is-referenced-by-count":9,"title":["Clinical immunology&lt;br&gt;Elastase and metalloproteinase-9 concentrations in saliva in patients with chronic periodontitis"],"prefix":"10.5114","volume":"39","author":[{"given":"Ma\u0142gorzata","family":"N\u0119dzi-G\u00f3ra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Kostrzewa-Janicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"G\u00f3rska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2014,10,14]]},"container-title":["Central European Journal of Immunology"],"original-title":[],"link":[{"URL":"https:\/\/ceji.termedia.pl\/pdf-57501-130191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ceji.termedia.pl\/pdf-57501-130191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T08:59:42Z","timestamp":1767949182000},"score":1,"resource":{"primary":{"URL":"https:\/\/ceji.termedia.pl\/Clinical-immunology-Elastase-and-metalloproteinase-9-concentrations-in-saliva-in,57501,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,14]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014]]}},"alternative-id":["57501"],"URL":"https:\/\/doi.org\/10.5114\/ceji.2014.45948","relation":{},"ISSN":["1426-3912","1644-4124"],"issn-type":[{"value":"1426-3912","type":"print"},{"value":"1644-4124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,14]]}}}