{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:39:08Z","timestamp":1791005948538,"version":"4.1.0"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","issue":"4","license":[{"start":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T00:00:00Z","timestamp":1418601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T00:00:00Z","timestamp":1418601600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T00:00:00Z","timestamp":1418601600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cent Eur J Immunol"],"abstract":"<jats:p>&lt;b&gt;Introduction&lt;\/b&gt;: It has been known that vitamin D has some immunomodulatory effects and in autoimmune thyroid diseases, vitamin D deficiency was more prevalent. In this study, our aim was to investigate the relationship between thyroid autoantibodies and vitamin D.&lt;br \/&gt;\n&lt;b&gt;Material and methods&lt;\/b&gt;: Group 1 and 2 consisted of 254 and 27 newly diagnosed Hashimoto\u2019s thyroiditis (HT) and Graves\u2019 disease (GD) cases, respectively; age-matched 124 healthy subjects were enrolled as controls (group 3). All subjects (n = 405) were evaluated for 25OHD and thyroid autoantibody [anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-tg)] levels.&lt;br \/&gt;\n&lt;b&gt;Results&lt;\/b&gt;: Group 2 and group 1 patients had lower 25OHD levels than group 3 subjects 14.9 \u00b18.6 ng\/ml, 19.4 \u00b110.1 ng\/ml and 22.5 \u00b115.4 ng\/ml, respectively (p &lt; 0.001). Serum 25OHD levels inversely correlated with anti-tg (r = \u20130.136, p = 0.025), anti-TPO (r = \u20130.176, p = 0.003) and parathormone (PTH) (r = \u20130.240, p &lt; 0.001). Group 2 patients had higher anti-tg and anti-TPO levels than group 1 and 3 (p &lt; 0.001).&lt;br \/&gt;\n&lt;b&gt;Conclusions&lt;\/b&gt;: In this study, we found that patients with autoimmune thyroid disease (AITD) present with lower vitamin D levels and GD patients have higher prevalence. Since we found an inverse correlation between vitamin D levels and thyroid antibody levels, we may suggest that vitamin D deficiency is one of the potential factors in pathogenesis of autoimmune thyroid disorders.<\/jats:p>","DOI":"10.5114\/ceji.2014.47735","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T09:43:27Z","timestamp":1422438207000},"page":"493-497","source":"Crossref","is-referenced-by-count":43,"title":["Clinical immunology&lt;br&gt;Vitamin D deficiency is related to thyroid antibodies in autoimmune thyroiditis"],"prefix":"10.5114","volume":"39","author":[{"given":"Asl\u0131 Dogruk","family":"Unal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Tarcin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hulya","family":"Parildar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Cigerli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hacer","family":"Eroglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilgun Guvener","family":"Demirag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2014,12,15]]},"container-title":["Central European Journal of Immunology"],"original-title":[],"link":[{"URL":"https:\/\/ceji.termedia.pl\/pdf-57503-130170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ceji.termedia.pl\/pdf-57503-130170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T08:59:33Z","timestamp":1767949173000},"score":1,"resource":{"primary":{"URL":"https:\/\/ceji.termedia.pl\/Clinical-immunology-Vitamin-D-deficiency-is-related-to-thyroid-antibodies-in-autoimmune,57503,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,15]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014]]}},"alternative-id":["57503"],"URL":"https:\/\/doi.org\/10.5114\/ceji.2014.47735","relation":{},"ISSN":["1426-3912","1644-4124"],"issn-type":[{"value":"1426-3912","type":"print"},{"value":"1644-4124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,15]]}}}