{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:11:46Z","timestamp":1767989506921,"version":"3.49.0"},"reference-count":20,"publisher":"Termedia Sp. z.o.o.","issue":"4","license":[{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cent Eur J Immunol"],"abstract":"<jats:p>&lt;b&gt;Introduction: &lt;\/b&gt;STAT4 is an important transcription factor that activates gene transcription as a response to cytokines. Recently, the influence of STAT4 gene on autoimmune disease has been widely studied in many different immune-related diseases. Autoimmune, metabolic and cardiovascular disorders are more common in psoriatic patients. STAT4 may be a unique gene that switches on in autoimmune-related thyroid disease in psoriatic patients.&lt;br \/&gt;\n&lt;b&gt;The aim of the study&lt;\/b&gt;: To explore the association of a STAT4 rs7574865 polymorphism to autoimmune thyroid diseases in the general Turkish population and psoriatic subgroups.&lt;br \/&gt;\n&lt;b&gt;Material and methods&lt;\/b&gt;: A total of 132 psoriatic patients and 118 non-psoriatic volunteers were genotyped for STAT4 rs7574865 using real time PCR. Twenty-four of the psoriatic patients and 15 of the non-psoriatic volunteers have autoimmune-related thyroid diseases.&lt;br \/&gt;\n&lt;b&gt;Results&lt;\/b&gt;: The prevalence of the T allele [OR = 4.37; 95% CI: 1.05-19; p = 0.03] of the STAT4 rs7574865 was higher in individuals with autoimmune-related thyroid diseases among the all non-psoriatic volunteers. The volunteers with autoimmune-related thyroid diseases has an increased allele positivity and carriers having at least one of the risk allele was significantly higher than in counterparts with a GG wild genotype [ORGT\/TT vs. GG: 1.73; 95% CI: 0.09-32; p = 0.03]. Yet, there was no evidence of an association between rs7574865 and autoimmune-related thyroid disease in psoriatic patients.&lt;br \/&gt;\n&lt;b&gt;Conclusions&lt;\/b&gt;: The STAT4 rs7574865 polymorphism increases autoimmune-related thyroid disease susceptibility among the general population but not in psoriatic patients.<\/jats:p>","DOI":"10.5114\/ceji.2015.57146","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T04:38:06Z","timestamp":1458621486000},"page":"437-441","source":"Crossref","is-referenced-by-count":7,"title":["Contribution of the &lt;i&gt;STAT4&lt;\/i&gt; rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups"],"prefix":"10.5114","volume":"40","author":[{"given":"Meliha M.","family":"HIZ","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevilay","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selda","family":"I\u015f\u0131k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zerrin","family":"Ogretmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"SIlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2016,1,15]]},"reference":[{"key":"ref-1557679","doi-asserted-by":"crossref","unstructured":"Thierfelder WE, van Deursen JM, Yamamoto K, et al. (1996): Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382: 171-174.","DOI":"10.1038\/382171a0"},{"key":"ref-1557680","doi-asserted-by":"crossref","unstructured":"Wurster AL, Tanaka T, Grusby MJ (2000): The biology of Stat4 and Stat6. Oncogene 19: 2577-2584.","DOI":"10.1038\/sj.onc.1203485"},{"key":"ref-1557681","doi-asserted-by":"crossref","unstructured":"Good SR, Thieu VT, Mathur AN, et al. (2009): Temporal Induction Pattern of STAT4 Target Genes Defines Potential for Th1 Lineage-Specific Programming. J Immunol 183: 3839-3847.","DOI":"10.4049\/jimmunol.0901411"},{"key":"ref-1557682","doi-asserted-by":"crossref","unstructured":"Liang Y, Pan HF, Ye DQ (2014): Therapeutic potential of STAT4 in autoimmunity. Expert Opin Ther Targets 18: 945-960.","DOI":"10.1517\/14728222.2014.920325"},{"key":"ref-1557683","doi-asserted-by":"crossref","unstructured":"Yan N, Meng S, Zhou J, et al. 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(2012): Association of STAT4 rs7574865 polymorphism with autoimmune diseases: a meta-analysis. Mol Biol Rep 39: 8873-8882.","DOI":"10.1007\/s11033-012-1754-1"},{"key":"ref-1557697","doi-asserted-by":"crossref","unstructured":"Land KJ, Gudapati P, Kaplan MH, Seetharamaiah GS (2006): Differential requirement of signal transducer and activator of transcription-4 (Stat4) and Stat6 in a thyrotropin receptor-289-adenovirus-induced model of Graves\u2019 hyperthyroidism. Endocrinology 147: 111-119.","DOI":"10.1210\/en.2005-1031"},{"key":"ref-1557698","doi-asserted-by":"crossref","unstructured":"Park Y, Lee HS, Park Y, et al. (2011): Evidence for the role of STAT4 as a general autoimmunity locus in the Korean population. 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