{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:13:15Z","timestamp":1780557195593,"version":"3.54.1"},"reference-count":31,"publisher":"Termedia Sp. z.o.o.","issue":"1","license":[{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cent Eur J Immunol"],"abstract":"<jats:p>&lt;b&gt;Aim of the study&lt;\/b&gt;: \u03b2-thalassaemia (\u03b2-Thal) is considered a\u00a0severe, progressive haemolytic anaemia, which needs regular blood transfusions for life expectancy. Complement-mediated erythrocyte destruction can cause both intravascular and extravascular haemolysis. Complement regulatory proteins protect cells from such effects of the complement system. We aimed to perform quantitative analysis of membrane-bound complement regulators, CD55 (decay accelerating factor \u2013 DAF), CD35 (complement receptor type 1 \u2013 CR1), and CD59 (membrane attack complex inhibitory factor \u2013 MACIF) on peripheral red blood cells by flow cytometry.&lt;br \/&gt;\n&lt;b&gt;Material and methods:&lt;\/b&gt; The present study was carried out on 47 \u03b2-thalassemia major (\u03b2-TM) patients, 20 \u03b2-thalassaemia intermedia (\u03b2-TI) patients, and 17 healthy volunteers as control subjects. &lt;br \/&gt;\n&lt;b&gt;Results&lt;\/b&gt;: CD55 levels of \u03b2-TM patients (58.64 \u00b117.06%) were significantly decreased compared to \u03b2-TI patients (83.34 \u00b113.82%) and healthy controls (88.57 \u00b111.69%) (p &lt; 0.01). CD59 levels of \u03b2-TM patients were not significantly different than \u03b2-TI patients and controls, but CD35 levels were significantly lower in the \u03b2-TM patients (3.56 \u00b14.87%) and \u03b2-TI patients (12.48 \u00b19.19%) than in the control group (39.98 \u00b115.01%) (p &lt; 0.01). &lt;br \/&gt;\n&lt;b&gt;Conclusions&lt;\/b&gt;: Low levels of CD55 and CD35 in thalassaemia major patients indicates a\u00a0role for them in the aetiopathogenesis of haemolysis in this disease, and also this defect in a\u00a0complement system may be responsible for the chronic complications seen in these patients.<\/jats:p>","DOI":"10.5114\/ceji.2017.67321","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T07:16:13Z","timestamp":1496214973000},"page":"78-84","source":"Crossref","is-referenced-by-count":10,"title":["Expression of CD55, CD59, and CD35 on red blood cells of \u03b2-thalassaemia patients"],"prefix":"10.5114","volume":"42","author":[{"given":"Ay\u015feg\u00fcl U\u011fur","family":"Kurto\u011fllu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belkls","family":"Ko\u00e7tekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdal","family":"Kurto\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selen","family":"Bozkurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2017,5,8]]},"reference":[{"key":"ref-1554614","doi-asserted-by":"crossref","unstructured":"Antonio C, Renzo G (2010): Beta-thalassemia. 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