{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T10:10:37Z","timestamp":1767953437277,"version":"3.49.0"},"reference-count":21,"publisher":"Termedia Sp. z.o.o.","issue":"2","license":[{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cent Eur J Immunol"],"abstract":"<jats:p>Aim of the study: The aim of the study was the assessment of changes in the glomerular filtration rate (GFR) during long-term observation in a group of systemic sclerosis (SSc) patients with and without chronic antiphospholipid (aPL) antibody positivity. &lt;br \/&gt;\nMaterial and methods: The observation comprised 50 patients \u2013 23 with diffuse cutaneous SSc \u2013 dcSSc and 27 limited cutaneous SSc \u2013 lcSSc. After 24 months we assessed 27 patients (9 died, 14 lost follow up); 24 patients (88%) were treated chronically with angiotensin-converting-enzyme inhibitors (ACEIs). Patients were investigated for the presence of aPL: to cardiolipin and to \uf0622 glycoprotein I in IgM and IgG classes. Serum levels of creatinine (S-Cr), cystatin C and creatinine clearance values were determined in all patients. According to the presence of a significant level of at least one of aPL antibodies, pts were divided into groups: group I aPL positive: 14 patients, group II aPL negative \u2013 13 patients. &lt;br \/&gt;\nResults: We did not find significant differences in S-Cr, cystatin C levels and creatinine clearance before and after 24 months of observation between both groups. In follow up observations, the presence of anti-centromere antibodies was significantly more frequent in the aPL positive, as compared to the aPL negative group (p = 0.01). In follow up observations, the level of anticardiolipin antibodies in IgG class was significantly higher in dcSSc compared to lcSSc patients (p = 0.02). &lt;br \/&gt;\nConclusions: In long-term observation chronic positivity for aPL antibodies does not significantly decrease the GFR in patients with SSc treated with ACEIs.<\/jats:p>","DOI":"10.5114\/ceji.2017.69358","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T05:19:17Z","timestamp":1503983957000},"page":"161-166","source":"Crossref","is-referenced-by-count":0,"title":["Influence of antiphospholipid antibody positivity on glomerular filtration rate markers in a group of systemic sclerosis patients \u2013 a 24-month observation"],"prefix":"10.5114","volume":"42","author":[{"given":"Ewa","family":"Wielosz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Majdan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arkadiusz","family":"Koszarny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Dryglewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Tabarkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2017,8,8]]},"reference":[{"key":"ref-1553787","doi-asserted-by":"crossref","unstructured":"Di Franco M, Paradiso M, Riccieri V, et al. (2007): Autonomic dysfunction and microvascular damage in systemic sclerosis. Clin Rheumatol 26: 1278-1283.","DOI":"10.1007\/s10067-006-0492-y"},{"key":"ref-1553788","doi-asserted-by":"crossref","unstructured":"Amin A, El-Sayed S, Taher N, Sedki M, et al. (2012): Tc-99m diethylenetriamine pentaacetic acid (DTPA) renal function reserve estimation: is it a reliable predictive tool for assessment of preclinical renal involvement in scleroderma patients? Clin Rheumatol 31: 961-966.","DOI":"10.1007\/s10067-012-1963-y"},{"key":"ref-1553789","doi-asserted-by":"crossref","unstructured":"Bose N, Chiesa-Vottero A, Chatterjee S (2015): Scleroderma renal crisis. Semin Arthritis Rheum 44: 687-694.","DOI":"10.1016\/j.semarthrit.2014.12.001"},{"key":"ref-1553790","doi-asserted-by":"crossref","unstructured":"Gigante A, Rosato E, Massa R, et al. (2012): Evaluation of Chronic Kidney Disease Epidemiology Collaboration equation to estimate glomerular filtration rate in scleroderma patients. 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(2013): Antiphospholipid antibodies and systemic scleroderma. Turk J Haematol 30: 32-36.","DOI":"10.4274\/tjh.2012.0059"},{"key":"ref-1553795","doi-asserted-by":"crossref","unstructured":"Gupta R, Thabah MM, Gupta S, et al. (2009): Clinical significance of antiphospholipid antibodies in Indian scleroderma patients. Rheumatol Int 30: 277-279.","DOI":"10.1007\/s00296-009-1107-0"},{"key":"ref-1553796","doi-asserted-by":"crossref","unstructured":"Ames PR (2009): Antiphospholipid antibodies in systemic sclerosis: a double oxidative hit? Clin Rheumatol 28: 881-882.","DOI":"10.1007\/s10067-009-1210-3"},{"key":"ref-1553797","doi-asserted-by":"crossref","unstructured":"Arslan Tas D (1980): Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classification of systemic sclerosis (scleroderma). 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(2014): The association of antiphospholipid antibodies with cardiopulmonary manifestations of systemic sclerosis. Clin Exp Rheumatol 32: 133-137."},{"key":"ref-1553806","unstructured":"Sysa-J\u0119drzejowska A, Zalewska A, Dziankowska-Bartkowiak B, Waszczykowska E (2004): Evaluation of serum vascular endothelial growth factor and endostatin in systemic sclerosis patients \u2013 correlation with lung and cardio-vascular system involvement. Centr Eur J Immunol 29: 15-22."},{"key":"ref-1553807","doi-asserted-by":"crossref","unstructured":"Milena K. Nikolova-Vlahova, Krasimir V, et al. (2015): Antiphospholipid antibodies in patients with upper-extremity deep vein thrombosis. 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