{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T10:16:49Z","timestamp":1767953809312,"version":"3.49.0"},"reference-count":27,"publisher":"Termedia Sp. z.o.o.","issue":"3","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cent Eur J Immunol"],"abstract":"<b>Introduction<\/b>: Adenosine and deoxyadenosine metabolism is influenced by adenosine deaminase (ADA) enzyme. ADA increases in different diseases and is considered as one of the markers for cell-mediated immunity. Pregnancy is associated with depressed cell-mediated immunity. The level of ADA expression, which seems to play a key role in maintaining pregnancy, is influenced by adenosine deaminase <I>G22A<\/I> gene polymorphism. We aimed in our study to evaluate the association of ADA <I>G22A<\/I> gene polymorphism with recurrent spontaneous abortion (RSA) in Egyptian women. <br \/>\n<b>Material and methods<\/b>: Adenosine deaminase <I>G22A<\/I> gene polymorphism was genotyped in 40 patients (age range 22-39 years) with a history of RSA, selected from those attending the Gynaecology and Obstetrics Clinic of Beni-Suef University Hospital, and 20 age-matched healthy women as a control group, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. <br \/>\n<b>Results<\/b>: In our study, no statistically significant difference was found between RSA patients and control group as regards ADA <I>G22A<\/I> genotypes (p = 0.653) and alleles (p = 0.697). A comparison of the frequencies of ADA alleles in RSA patients as regards the below-35-years-old age group revealed that ADA 2(A) allele was associated with a low risk for RSA in patients aged 35 years old or younger (p = 0.008). <br \/>\n<b>Conclusions<\/b>: In conclusion, our study revealed an age-dependent protective value of ADA 2(A) allele in recurrent spontaneous abortions among the Egyptian population.<\/jats:p>","DOI":"10.5114\/ceji.2017.70972","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T08:09:48Z","timestamp":1511510988000},"page":"281-286","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the adenosine deaminase (ADA) <I>G22A<\/I> gene polymorphism with recurrent spontaneous abortion among Egyptian patients"],"prefix":"10.5114","volume":"42","author":[{"given":"Hanan Mohamed","family":"Farhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadiga","family":"Abu-Gabal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha","family":"Katta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghda","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2017,10,30]]},"reference":[{"key":"ref-1553253","unstructured":"Schorge JO, Schaffer JI, Halvorson LM, et al. 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