{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T09:56:29Z","timestamp":1781949389842,"version":"3.54.5"},"reference-count":27,"publisher":"Termedia Sp. z.o.o.","issue":"4","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cent Eur J Immunol"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hypersensitivity pneumonitis (HP) is the third most common interstitial lung disease, and is often under-recognized, especially in patients who are not aware of their occupational or environmental contact with organic antigens. The aim of the present study was to assess the results of serum specific IgG antibodies (ssIgG) in HP patients and their correlation with clinical data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>128 HP patients, median age 53 years, participated in the study. The control group consisted of 102 patients with interstitial lung diseases (ILDs) other than HP. Assessment of pretreatment ssIgG to thermophilic actinomycetes and protein antigens from bird droppings (pigeons, hens, ducks, parrots, turkeys) was performed by double diffusion in agar gel according to Ouchterlony method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Positive precipitins were obtained in 57% of all HP patients and in 61% of those exposed to above mentioned antigens. Positive results in the control group were obtained in 7% of patients. Sensitivity of ssIgG in HP group was 0.57 and specificity 0.93. Precipitins to at least one bird antigen was confirmed in 64% of HP patients exposed to birds. Precipitins to thermophilic bacteria were found in 29% of HP patients exposed to hay or hay products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of the study indicate that ssIgG against birds\u2019 allergens were the valuable diagnostic tool in HP patients. Low-rate of confirmation of ssIgG to thermophilic bacteria in patients exposed to hay or hay products indicate that other microorganisms, most likely molds, could be responsible for the disease development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5114\/ceji.2019.92791","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T03:44:13Z","timestamp":1582688653000},"page":"390-394","source":"Crossref","is-referenced-by-count":11,"title":["The value of serum precipitins against specific antigens in patients diagnosed with hypersensitivity pneumonitis \u2013 retrospective study"],"prefix":"10.5114","volume":"44","author":[{"given":"Monika","family":"Szturmowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Garczewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata E.","family":"J\u0119drych","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Bartoszuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Sobiecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Witold","family":"Tomkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Augustynowicz-Kope\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"ref-1547314","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.rmed.2013.09.002","article-title":"A cohort study of interstitial lung diseases in central","volume":"108","author":"Hyldgaard C","year":"2014","unstructured":"Hyldgaard C, Hilberg O, Muller A, Bendstrup E (2014): A cohort study of interstitial lung diseases in central Denmark Respir Med 108: 793-799.","journal-title":"Denmark Respir Med"},{"key":"ref-1547315","doi-asserted-by":"crossref","first-page":"180076","DOI":"10.1183\/16000617.0076-2018","article-title":"Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases","volume":"27","author":"Cottin V","year":"2018","unstructured":"Cottin V, Hirani NA, Hotchkin DL, et al. (2018): Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases. Eur Respir Rev 27: 180076.","journal-title":"Eur Respir Rev"},{"key":"ref-1547316","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1513\/AnnalsATS.201704-288OC","article-title":"Epidemiology of hypersensitivity pneumonitis among an insured population in the United States: a claims-based cohort analysis","volume":"15","author":"Fernandez Perez E","year":"2018","unstructured":"Fernandez Perez E, Kong A, Raimundo K, et al. (2018): Epidemiology of hypersensitivity pneumonitis among an insured population in the United States: a claims-based cohort analysis. Annals ATS 15: 460-469.","journal-title":"Annals ATS"},{"key":"ref-1547317","first-page":"523","article-title":"Analiza grupy chorych na \u015br\u00f3dmi\u0105\u017bszowe choroby p\u0141uc hospitalizowanych w latach 2000-2009 na oddziale p\u0141ucnym wojew\u00f3dzkiego szpitala w Radomiu","volume":"80","author":"Szafra\u0143ski W","year":"2012","unstructured":"Szafra\u0143ski W (2012): Analiza grupy chorych na \u015br\u00f3dmi\u0105\u017bszowe choroby p\u0141uc hospitalizowanych w latach 2000-2009 na oddziale p\u0141ucnym wojew\u00f3dzkiego szpitala w Radomiu. Pneumonol Alergol Pol 80: 523-532.","journal-title":"Pneumonol Alergol Pol"},{"key":"ref-1547318","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1164\/rccm.201611-2201PP","article-title":"Hypersensitivity pneumonitis: perspectives in diagnosis and management","volume":"196","author":"Vasakova M","year":"2017","unstructured":"Vasakova M, Morell F, Walsh S, et al. (2017): Hypersensitivity pneumonitis: perspectives in diagnosis and management. Am J Respir Crit Care Med 196: 680-689.","journal-title":"Am J Respir Crit Care Med"},{"key":"ref-1547319","doi-asserted-by":"crossref","first-page":"1800443","DOI":"10.1183\/13993003.00443-2018","article-title":"Development and validation of radiological diagnosis model for hypersensitivity pneumonitis","volume":"52","author":"Salisbury ML","year":"2018","unstructured":"Salisbury ML, Gross BH, Chughtai A, et al. (2018): Development and validation of radiological diagnosis model for hypersensitivity pneumonitis. Eur Respir J 52: 1800443.","journal-title":"Eur Respir J"},{"key":"ref-1547320","doi-asserted-by":"crossref","first-page":"159","DOI":"10.5114\/ceji.2016.60990","article-title":"Macrophage polarization in interstitial lung diseases","volume":"41","author":"Wojtan P","year":"2016","unstructured":"Wojtan P, Mierzejewski M, Osi\u0143ska I, Domaga\u0141a-Kulawik J (2016): Macrophage polarization in interstitial lung diseases. Cent Eur J Immunol 41: 159-164.","journal-title":"Cent Eur J Immunol"},{"key":"ref-1547321","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1164\/rccm.201608-1675PP","article-title":"Diagnosis and treatment of fibrotic hypersensitivity pneumonia. Where we stand and where we need to go","volume":"196","author":"Salisbury ML","year":"2017","unstructured":"Salisbury ML, Myers JL, Belloli EA, et al. (2017): Diagnosis and treatment of fibrotic hypersensitivity pneumonia. Where we stand and where we need to go. Am J Respir Crit Care Med 196: 690-699.","journal-title":"Am J Respir Crit Care Med"},{"key":"ref-1547322","doi-asserted-by":"crossref","first-page":"109","DOI":"10.5858\/arpa.2017-0173-RA","article-title":"Pathology of chronic hypersensitivity pneumonitis. What is it? What are the diagnostic criteria? Why do we care?","volume":"142","author":"Churg A","year":"2018","unstructured":"Churg A, Bilawich AM, Wright JL (2018): Pathology of chronic hypersensitivity pneumonitis. What is it? What are the diagnostic criteria? Why do we care? Arch Pathol Lab Med 142: 109-119.","journal-title":"Arch Pathol Lab Med"},{"key":"ref-1547323","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1055\/s-0036-1580692","article-title":"Hypersensitivity pneumonitis: challenges in diagnosis and management, avoiding surgical lung biopsy","volume":"37","author":"Morell F","year":"2016","unstructured":"Morell F, Villar A, Ojanguren I, et al. (2016): Hypersensitivity pneumonitis: challenges in diagnosis and management, avoiding surgical lung biopsy. Semin Respir Crit Care Med 37: 395-405.","journal-title":"Semin Respir Crit Care Med"},{"key":"ref-1547324","doi-asserted-by":"crossref","first-page":"83","DOI":"10.5603\/ARM.2019.0014","article-title":"Hypersensitivity pneumonitis recognised in single pulmonary unit, between 2005 and 2015, comparison with recently proposed diagnostic criteria","volume":"87","author":"Szturmowicz M","year":"2019","unstructured":"Szturmowicz M, Bara\u0143ska I, J\u0118drych ME et al. (2019): Hypersensitivity pneumonitis recognised in single pulmonary unit, between 2005 and 2015, comparison with recently proposed diagnostic criteria. Adv Respir Med 87: 83-89.","journal-title":"Adv Respir Med"},{"key":"ref-1547325","first-page":"39","article-title":"Bird fancier\u2019s lung: clinical-radiological presentation in 15 cases","volume":"83","author":"Kumar R","year":"2015","unstructured":"Kumar R, Singh M (2015): Bird fancier\u2019s lung: clinical-radiological presentation in 15 cases. Pneumonol Alergol Pol 83: 39-44.","journal-title":"Pneumonol Alergol Pol"},{"key":"ref-1547326","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/iid3.202","article-title":"Environmental levels of avian proteins are relevant to the progression of chronic hypersensitivity pneumonitis during antigen avoidance","volume":"6","author":"Sema M","year":"2018","unstructured":"Sema M, Miyazaki Y, Tsutsui T, et al. (2018): Environmental levels of avian proteins are relevant to the progression of chronic hypersensitivity pneumonitis during antigen avoidance. Immun Inflamm Dis 6: 154-162.","journal-title":"Immun Inflamm Dis"},{"key":"ref-1547327","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1164\/rccm.201710-1986OC","article-title":"Identification of diagnostic criteria for chronic hypersensitivity pneumonitis. An International Modified Delphi Survey","volume":"197","author":"Morisset J","year":"2018","unstructured":"Morisset J, Johannson KA, Jones KD, et al. (2018): Identification of diagnostic criteria for chronic hypersensitivity pneumonitis. An International Modified Delphi Survey. Am J Respir Crit Care Med 197: 1036-1044.","journal-title":"Am J Respir Crit Care Med"},{"key":"ref-1547328","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.rmed.2017.06.019","article-title":"Diagnostic implications of positive avian serology in suspected hypersensitivity pneumonitis","volume":"129","author":"Woge MJ","year":"2017","unstructured":"Woge MJ, Ryu JH, Moua T (2017): Diagnostic implications of positive avian serology in suspected hypersensitivity pneumonitis. Respir Med 129: 173-178.","journal-title":"Respir Med"},{"key":"ref-1547329","doi-asserted-by":"crossref","first-page":"517","DOI":"10.13075\/mp.5893.00406","article-title":"Hypersensitivity pneumonitis: Diagnostic criteria, treatment, prognosis and prevention","volume":"67","author":"J\u0118drych ME","year":"2016","unstructured":"J\u0118drych ME, Szturmowicz M, Bestry I, Ku\u015b J (2016): Hypersensitivity pneumonitis: Diagnostic criteria, treatment, prognosis and prevention. Med Pr 67: 517-527.","journal-title":"Med Pr"},{"key":"ref-1547330","doi-asserted-by":"crossref","first-page":"164","DOI":"10.5603\/ARM.2017.0029","article-title":"Signalling pathways and their miRNA regulators involved in the etiopathology of idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP)","volume":"85","author":"Kisza\u0141kiewicz J","year":"2017","unstructured":"Kisza\u0141kiewicz J, Piotrowski W, Brzezia\u0143ska-Lasota E, et al. (2017): Signalling pathways and their miRNA regulators involved in the etiopathology of idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP). Adv Respir Med 85: 164-178.","journal-title":"Adv Respir Med"},{"key":"ref-1547331","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.resinv.2014.08.001","article-title":"Utility of immunological tests for bird-related hypersensitivity pneumonitis","volume":"53","author":"Suhara K","year":"2015","unstructured":"Suhara K, Miyazaki Y, Okamoto T, et al. (2015): Utility of immunological tests for bird-related hypersensitivity pneumonitis. Respir Investig 53: 13-21.","journal-title":"Respir Investig"},{"key":"ref-1547332","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/jcp.45.6.490","article-title":"Comparison of immunodiffusion and enzyme-linked immunosorbent assay in the detection of abnormal antibodies in pigeon breeder\u2019s disease","volume":"45","author":"Simpson C","year":"1992","unstructured":"Simpson C, Shirodaria PV, Evans JP, et al. (1992): Comparison of immunodiffusion and enzyme-linked immunosorbent assay in the detection of abnormal antibodies in pigeon breeder\u2019s disease. J Clin Pathol 45: 490-493.","journal-title":"J Clin Pathol"},{"key":"ref-1547333","first-page":"609","article-title":"Przydatno\u015b\u0106 antygen\u00f3w wyizolowanych z wydalin go\u0141\u0118bi do pr\u00f3b serologicznych w rozpoznawaniu AZPP u hodowc\u00f3w go\u0141\u0118bi","volume":"48","author":"Meleniewska-Maciszewska A","year":"1980","unstructured":"Meleniewska-Maciszewska A (1980): Przydatno\u015b\u0106 antygen\u00f3w wyizolowanych z wydalin go\u0141\u0118bi do pr\u00f3b serologicznych w rozpoznawaniu AZPP u hodowc\u00f3w go\u0141\u0118bi. Pneumonol Pol 48: 609-617.","journal-title":"Pneumonol Pol"},{"key":"ref-1547334","first-page":"149","article-title":"Utility of precipitating antibody testing in the diagnostic evaluation of chronic hypersensitivity pneumonia","volume":"34","author":"De Giacomi F","year":"2017","unstructured":"De Giacomi F, Andreano A, Faverio P, et al. (2017): Utility of precipitating antibody testing in the diagnostic evaluation of chronic hypersensitivity pneumonia. Sarcoid Vasc Diffuse Lung Dis 34: 149-155.","journal-title":"Sarcoid Vasc Diffuse Lung Dis"},{"key":"ref-1547335","first-page":"699","article-title":"Hypersensitivity pneumonitis radiologic phenotypes are associated with distinct survival time and pulmonary function trajectory","volume":"155","author":"Salisbury ML","year":"2019","unstructured":"Salisbury ML, Gu T, Murray S, et al. (2019): Hypersensitivity pneumonitis radiologic phenotypes are associated with distinct survival time and pulmonary function trajectory. Chest 155: 699-711.","journal-title":"Chest"},{"key":"ref-1547336","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.chest.2016.10.029","article-title":"Use of mycophenolate mofetil or azathioprine for the management of chronic hypersensitivity pneumonitis","volume":"151","author":"Morisset J","year":"2017","unstructured":"Morisset J, Johannson KA, Vittinghoff E, et al. (2017): Use of mycophenolate mofetil or azathioprine for the management of chronic hypersensitivity pneumonitis. Chest 151: 619-625.","journal-title":"Chest"},{"key":"ref-1547337","first-page":"97","article-title":"Hypersensitivity pneumonitis: antigen diversity and disease implications","volume":"25","author":"Nogueira R","year":"2019","unstructured":"Nogueira R, Melo N, Novais e Bastos H, et al. (2019): Hypersensitivity pneumonitis: antigen diversity and disease implications. Pneumonol 25: 97-108.","journal-title":"Pneumonol"},{"key":"ref-1547338","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1365-2362.2010.02327.x","article-title":"Antigen specific IgG antibodies in feather duvet lung","volume":"40","author":"Koschel D","year":"2010","unstructured":"Koschel D, Luetzkendorf L (2010): Antigen specific IgG antibodies in feather duvet lung. Eur J Clin Invest 40: 797-802.","journal-title":"Eur J Clin Invest"},{"key":"ref-1547339","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jaci.2012.03.039","article-title":"Aspergillus species recombinant antigens for serodiagnosis of farmer\u2019s lung disease","volume":"130","author":"Millon L","year":"2012","unstructured":"Millon L, Roussel S, Rognon B, et al. (2012): Aspergillus species recombinant antigens for serodiagnosis of farmer\u2019s lung disease. J Allergy Clin Immunol 130: 803-805.","journal-title":"J Allergy Clin Immunol"},{"key":"ref-1547340","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1099\/jmm.0.000037","article-title":"Western blotting as a tool for the serodiagnosis of farmer\u2019s lung disease: validation with Lichtheimia corymbifera protein extracts","volume":"64","author":"Rognon B","year":"2015","unstructured":"Rognon B, Reboux G, Roussel S, et al. (2015): Western blotting as a tool for the serodiagnosis of farmer\u2019s lung disease: validation with Lichtheimia corymbifera protein extracts. J Med Microbiol 64: 359-368.","journal-title":"J Med Microbiol"}],"container-title":["Central European Journal of Immunology"],"original-title":[],"link":[{"URL":"https:\/\/ceji.termedia.pl\/pdf-111778-129817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ceji.termedia.pl\/pdf-111778-129817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T08:35:47Z","timestamp":1767947747000},"score":1,"resource":{"primary":{"URL":"https:\/\/ceji.termedia.pl\/The-value-of-serum-precipitins-against-specific-antigens-in-patients-diagnosed-with,111778,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,20]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019]]}},"alternative-id":["111778"],"URL":"https:\/\/doi.org\/10.5114\/ceji.2019.92791","relation":{},"ISSN":["1426-3912","1644-4124"],"issn-type":[{"value":"1426-3912","type":"print"},{"value":"1644-4124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,20]]}}}