{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T10:00:36Z","timestamp":1767952836744,"version":"3.49.0"},"reference-count":19,"publisher":"Termedia Sp. z.o.o.","issue":"4","license":[{"start":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T00:00:00Z","timestamp":1611964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T00:00:00Z","timestamp":1611964800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T00:00:00Z","timestamp":1611964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cent Eur J Immunol"],"abstract":"<jats:p>Tubulointerstitial nephritis (TIN) is an inflammatory process primarily involving the renal interstitium and is the cause of acute kidney injury (AKI) in 3-7% of cases confirmed by renal biopsy in children. Aciclovir may have a\u00a0nephrotoxic effect by crystallization in renal tubules or by inducing an immunologic process that leads to development of TIN.&lt;br \/&gt;\nWe report 2 male patients, aged 10 and 8 years, with nephrotic syndrome (NS), in whom disease relapse was triggered by varicella zoster infection. The patients received intravenous aciclovir which resulted in AKI due to acute TIN with the glomerular filtration rate 19.5 and 24.9 ml\/min\/1.73 m2, respectively. The diagnosis was confirmed by kidney biopsy in one of these patients. Initiation of glucocorticosteroids and withdrawal of aciclovir resulted in resolution of proteinuria and symptoms of AKI. &lt;br \/&gt;\nIn children with active NS treated with intravenous aciclovir, a\u00a0possibility of AKI due to TIN should be taken into account.<\/jats:p>","DOI":"10.5114\/ceji.2020.103426","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T16:32:16Z","timestamp":1615912336000},"page":"494-497","source":"Crossref","is-referenced-by-count":1,"title":["Acute tubulointerstitial nephritis following aciclovir treatment for chickenpox in children with nephrotic syndrome \u2013 a\u00a0report of two cases"],"prefix":"10.5114","volume":"45","author":[{"given":"Ma\u0142gorzata","family":"Pa\u0144czyk-Tomaszewska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Ku\u017ama-Mroczkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Skrzypczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Szymanik-Grzelak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadwiga","family":"Ma\u0142dyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2021,1,30]]},"reference":[{"key":"ref-1544858","doi-asserted-by":"crossref","first-page":"149","DOI":"10.5414\/CN10838","article-title":"Acute interstitial nephritis\u2013a reappraisal and update","volume":"82","author":"Raghavan R","year":"2014","unstructured":"Raghavan R, Eknoyan G (2014): Acute interstitial nephritis\u2013a reappraisal and update. 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