{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:05:46Z","timestamp":1787497546162,"version":"build-2736575974"},"reference-count":40,"publisher":"Termedia Sp. z.o.o.","issue":"1","license":[{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cent Eur J Immunol"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Infection and inflammation of the reproductive tract by Chlamydia trachomatis (CT) are recognized as significant risk factors for male infertility. This study aimed to evaluate CT infection and its effects on seminal parameters and cytokines in asymptomatic patients with teratozoospermia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>Semen samples from one hundred four male patients were collected, and CT detection was performed by polymerase chain reaction (PCR). The quality (volume, sperm concentration, pH, motility, morphology, and leucocytes) of the semen was measured by standard procedures recommended by the World Health Organization (WHO). Pro-inflammatory cytokines [interleukin (IL)-1\uf062, IL-6, IL-8, tumor necrosis factor \uf061 (TNF-\uf061), and interferon \uf067 (IFN-\uf067)], as well as anti-inflammatory cytokines (IL-4, IL-10), were determined by using enzyme-linked immunosorbent assay (ELISA). The frequency of CT infection was expressed as a\u00a0percentage. Descriptive statistics were used for comparison of cytokines from infertile men, and then the Mann-Whitney U\u00a0test was applied for the contrast of seminal parameters and cytokines from CT-infected &lt;i&gt;&lt;i&gt;&lt;i&gt;&lt;i&gt;&lt;i&gt;versus&lt;\/i&gt;&lt;\/i&gt;&lt;\/i&gt;&lt;\/i&gt;&lt;\/i&gt; non-CT infected men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A\u00a0ratio of 33\/104 (31.7%) patients were positive for CT infection. The ejaculate of positive CT infection was found to have increased pH (pH = 7.65 in non-CT infected vs. 7.94 CT-infected men; p = 0.026). High levels of pro-inflammatory cytokines were found in the population studied; however, infected males were noted to have high levels of IL-1\uf062 [184.66 (0-3985.33 pg\/ml), p = 0.001] and IL-6 [87.8 (0-1042.8 pg\/ml), p = 0.001].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CT infection increased seminal pH, as well as IL-1\uf062 and IL-6 cytokines, suggesting a\u00a0potential role of infection and inflammation in asymptomatic patients with teratozoospermia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5114\/ceji.2021.105247","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T16:24:38Z","timestamp":1620318278000},"page":"76-81","source":"Crossref","is-referenced-by-count":5,"title":["Seminal pro-inflammatory cytokines\nand pH are affected by Chlamydia infection\nin asymptomatic patients with teratozoospermia"],"prefix":"10.5114","volume":"46","author":[{"given":"Elvia","family":"P\u00e9rez-Soto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rigoberto","family":"Oros-Pantoja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Fern\u00e1ndez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Manuel Carbonell-Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"S\u00e1nchez Monroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2021,4,18]]},"reference":[{"key":"ref-1542957","author":"World Health Organization, Department of Reproductive Health and Research","year":"2010","unstructured":"World Health Organization, Department of Reproductive Health and Research (2010): WHO laboratory manual for the examination and processing of human semen, 5th ed. 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