{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:49:34Z","timestamp":1775645374449,"version":"3.50.1"},"reference-count":49,"publisher":"Termedia Sp. z.o.o.","issue":"3","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cent Eur J Immunol"],"abstract":"<jats:p>Limbal epithelial stem cells (LSC, LESC) are multipotent cells used as regenerative treatment of the cornea in patients with limbal epithelial stem cell deficiency (LSCD, LESCD).&lt;br \/&gt;\nThere are different types of stem cell grafting including cultivated limbal epithelial transplantation (CET) and simple limbal epithelial transplantation (SLET). The outcomes of the techniques have been assessed as similar, with differences in the sample size required during the procedures.&lt;br \/&gt;\nThe most important culture components for stem cell cultivation include 3T3 murine fibroblasts, human amniotic membrane (HAM), fibrin gel, and culture medium. The culture medium may be enriched with serum or not; however, xenobiotic-free materials are preferred because of the low risk of pathogen transmission.&lt;br \/&gt;\nMultiple studies have defined molecules important for maintaining the function of LSC including C\/EBP\u03b4, Bmi-1, p63\u03b1, interleukins (IL-6), epithelial structural proteins \u2013 keratins, and antibodies against epidermal growth factor receptor (EGFR). The cell phenotype of LSC has been described with factors of transplantation success rate such as a high percentage of p63 positive cells.&lt;br \/&gt;\nThe article emphasizes the role of recipient tissue preparation, modern cultivation techniques and pathophysiological processes in LSC transplantation effectiveness.<\/jats:p>","DOI":"10.5114\/ceji.2023.132033","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T02:10:00Z","timestamp":1697767800000},"page":"245-250","source":"Crossref","is-referenced-by-count":4,"title":["The immunology of corneal limbal stem cells: the up-to-date approach to stem cell transplantation"],"prefix":"10.5114","volume":"48","author":[{"given":"Katarzyna","family":"Samelska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Kupis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Szymanek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Izdebska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Zaleska-\u017bmijewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Skopi\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"ref-1536768","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/vop.12298","article-title":"Comparative morphological evaluation of domestic animal cornea","volume":"19","author":"Nautscher N","year":"2016","unstructured":"Nautscher N, Bauer A, Steffl M, Amselgruber WM (2016): Comparative morphological evaluation of domestic animal cornea. 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