{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:42:14Z","timestamp":1771051334319,"version":"3.50.1"},"reference-count":22,"publisher":"Termedia Sp. z.o.o.","issue":"2","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cent Eur J Immunol"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The presence of patients with latent tuberculosis infection (LTBI) has fueled the tuberculosis pandemic. We aimed to investigate the immune status of NK cells in LTBI patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>Twenty-one LTBI patients, 25 active pulmonary tuberculosis (APTB) patients and 25 healthy controls (HCs) participated in our research. The markers of NK cells were detected by flow cytometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The absolute number of circulating CD56&lt;sup&gt;bright&lt;\/sup&gt; and CD56&lt;sup&gt;dim&lt;\/sup&gt; NK cells in LTBI patients was higher than that of APTB patients, but the frequency of HLA-DR&lt;sup&gt;+&lt;\/sup&gt; CD56&lt;sup&gt;bright&lt;\/sup&gt; NK cells was significantly lower than that of HCs and APTB patients. Also, LTBI patients with CD56&lt;sup&gt;bright&lt;\/sup&gt; NK cells had intracellular levels of granzyme B that were as significantly elevated as those with APTB patients, but the levels of granzyme A and perforin were reduced. Meanwhile, the frequencies of CXCR3&lt;sup&gt;+&lt;\/sup&gt; NK cells, CXCR3&lt;sup&gt;+&lt;\/sup&gt; CD56&lt;sup&gt;bright&lt;\/sup&gt; and CXCR3&lt;sup&gt;+&lt;\/sup&gt; CD56&lt;sup&gt;dim&lt;\/sup&gt; NK cells were significantly lower in LTBI patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Circulating CD56&lt;sup&gt;bright&lt;\/sup&gt; NK cells exerted a significant role in maintaining immune balance in LTBI patients. An elevated frequency of granzyme B&lt;sup&gt;+&lt;\/sup&gt; CD56&lt;sup&gt;bright&lt;\/sup&gt; NK cells and a reduced frequency of perforin&lt;sup&gt;+&lt;\/sup&gt; CD56&lt;sup&gt;bright&lt;\/sup&gt; NK cells were effective in differentiating LTBI patients from HCs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5114\/ceji.2024.142104","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T05:22:23Z","timestamp":1724131343000},"page":"105-112","source":"Crossref","is-referenced-by-count":2,"title":["Changes in immune status of circulating NK cells in patients with latent tuberculosis infection"],"prefix":"10.5114","volume":"49","author":[{"given":"Shuang","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangfeng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuguo","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"ref-1535148","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1056\/NEJMra1405427","article-title":"Latent Mycobacterium tuberculosis infection","volume":"372","author":"Getahun H","year":"2015","unstructured":"Getahun H, Matteelli A, Chaisson RE, Raviglione M (2015): Latent Mycobacterium tuberculosis infection. 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