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The search was completed in March 2024 based on research databases, and the language of publication was restricted to English. The primary outcome measure was RE, and it was categorized into three subgroups: Zone 1 (Z1), Zone 2 (Z2), and Zone 3 (Z3). The secondary outcomes assessed were maximal oxygen uptake (VO2max) and blood lactate concentration. HIIT significantly improved RE compared to MICT (SMD = 0.44, 95% CI [0.15, 0.72], Z = 3.01, p &lt; 0.05). MICT showed a greater effect on VO2max (MD = 2.48, 95% CI [1.61, 3.34], Z = 5.60, p &lt; 0.05). HIIT was more effective at reducing blood lactate levels (MD = \u22120.15, 95% CI [\u22120.28, \u22120.02], Z = 2.20, p &lt; 0.05). The results indicate that HIIT was more effective than MICT in enhancing RE and delaying lactate accumulation. HIIT can further improve RE and postpone blood lactate accumulation when performed at or below the lactate threshold (\u2264 Z2). VO2max was more pronounced with MICT. These findings suggest that endurance runners and coaches should choose appropriate methods to optimize physiological adaptations.<\/jats:p>","DOI":"10.5114\/jhk\/205427","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:53:13Z","timestamp":1758635593000},"source":"Crossref","is-referenced-by-count":3,"title":["High-Intensity Interval Training and Moderate-Intensity Continuous Training Affect Running Economy in Endurance Runners: A Systematic Review and Meta-Analysis \nof Randomized Controlled Trials"],"prefix":"10.5114","author":[{"given":"Yangya","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"ref-1517113","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2021-105181"},{"key":"ref-1517114","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-014-0246-y"},{"key":"ref-1517115","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1333263"},{"key":"ref-1517116","doi-asserted-by":"publisher","DOI":"10.1123\/ijspp.2017-0015"},{"key":"ref-1517117","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.05.046"},{"key":"ref-1517118","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-013-0066-5"},{"key":"ref-1517119","doi-asserted-by":"publisher","DOI":"10.1123\/ijspp.2021-0435"},{"key":"ref-1517120","doi-asserted-by":"publisher","DOI":"10.3390\/nu13031033"},{"key":"ref-1517121","doi-asserted-by":"publisher","DOI":"10.1007\/s10916-018-0907-8"},{"key":"ref-1517122","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.285254"},{"key":"ref-1517123","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-022-01706-y"},{"key":"ref-1517124","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-819945"},{"key":"ref-1517125","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00875.2007"},{"key":"ref-1517126","doi-asserted-by":"publisher","DOI":"10.1113\/JP277250"},{"key":"ref-1517127","doi-asserted-by":"publisher","DOI":"10.1139\/h06-080"},{"key":"ref-1517128","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13857"},{"key":"ref-1517129","doi-asserted-by":"publisher","DOI":"10.5114\/jhk\/185637"},{"key":"ref-1517130","doi-asserted-by":"publisher","DOI":"10.1123\/ijspp.4.1.110"},{"key":"ref-1517131","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00138.2018"},{"key":"ref-1517132","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychsport.2022.102295"},{"key":"ref-1517133","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e3181cc2291"},{"key":"ref-1517134","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2006.05.014"},{"key":"ref-1517135","doi-asserted-by":"publisher","DOI":"10.70252\/ULIC9262"},{"key":"ref-1517136","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18168386"},{"key":"ref-1517137","doi-asserted-by":"crossref","unstructured":"Farrell, P. 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