{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:53:28Z","timestamp":1782208408450,"version":"3.54.5"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>Antigen Ki-67 is a non-histone nuclear protein, closely connected with cell proliferation. Determining Ki-67 allows for a quick and reliable evaluation of the growth fraction of the studied cell population. It serves as a marker of proliferative activity in neoplasms and other diseases with excessive cell proliferation such as psoriasis.&lt;br \/&gt;\nEvaluation of Ki-67 expression in epidermal cells was performed in 10 individuals suffering from plaque psoriasis, before and after one of three methods of phototherapy: broadband UVB, narrowband UVB or PUVA. &lt;br \/&gt;\nWe observed increased Ki-67 antigen expression in psoriatic lesions. The percentage of Ki-67 positive nuclei in the epidermis affected by the disease ranged from 0 to 30% and in the macroscopically healthy surrounding tissue the percentage was from 0 to 10%. &lt;br \/&gt;\nAfter phototherapy the expression in lesional skin decreased (p &lt; 0.01). The greatest decrease was observed after the application of PUVA therapy (from 25 to 10% of cells, p &lt; 0.05). No significant differences were observed in the perilesional skin with regard to Ki-67 antigen expression before or after phototherapy. &lt;br \/&gt;\nOn the basis of our own study and studies conducted by other researchers, it can be concluded that reduced Ki-67 expression after the application of PUVA and UVB therapies in the psoriatic epidermis is not a characteristic result of phototherapy only. It is a characteristic property of any effective psoriasis therapy.<\/jats:p>","DOI":"10.5114\/pjp.2013.36006","type":"journal-article","created":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T05:05:21Z","timestamp":1381122321000},"page":"96-103","source":"Crossref","is-referenced-by-count":9,"title":["Influence of phototherapy in psoriasis on ki-67 antigen expression: a preliminary study"],"prefix":"10.5114","volume":"64","author":[{"given":"Dorota","family":"Jesionek-Kupnicka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Chomiczewska-Sk\u00f3ra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Rotsztejn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2013,7,15]]},"container-title":["Polish Journal of Pathology"],"original-title":[],"link":[{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-54544-137223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-54544-137223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:39:37Z","timestamp":1782207577000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polishjournalofpathology.com\/Influence-of-phototherapy-in-psoriasis-on-ki-67-antigen-expression-a-preliminary,54544,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,15]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013]]}},"alternative-id":["54544"],"URL":"https:\/\/doi.org\/10.5114\/pjp.2013.36006","relation":{},"ISSN":["1233-9687","2084-9869"],"issn-type":[{"value":"1233-9687","type":"print"},{"value":"2084-9869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,15]]}}}