{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:53:40Z","timestamp":1782208420149,"version":"3.54.5"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>Recurrent respiratory papillomatosis is an increasingly common disease which leads to organic and functional limitations. Clinical symptoms depend on the location and extent of the papillomatosis. They include hoarseness, cough, and, in some cases, significant narrowing of the respiratory and digestive tracts.&lt;br \/&gt;\nThe present report describes a\u00a0fatal case of a\u00a0young man (28 years old) who developed a\u00a0very dynamic papilloma infection of the larynx, which spread to the trachea, the oesophagus, the soft tissues of the neck, and the mediastinum. Multimodal treatment did not stop the progression of the disease.&lt;br \/&gt;\nThe papillomatous lesion was removed with a\u00a0CO&lt;sub&gt;2&lt;\/sub&gt; laser used in a\u00a0Kleinsasser microlaryngoscopy and under a\u00a0microscope using a\u00a0electrocoagulation loop with argon plasma during the gastroscopy. Antiviral treatment with cidofovir was introduced, as well as in further follow-up radiotherapy. Congenital or acquired immunodeficiency was also excluded.&lt;br \/&gt;\nDespite multimodal treatment, successful eradication of the infection was not possible. In our case, aggressive progression of the disease was observed. We were unable to confirm malignant transformation. Papillomatosis was the only disease, and its aggressive development led to the patient\u2019s death. In the case of aggressive, uncontrolled progression \u2013 when the infiltration spreads beyond the larynx and the hypopharynx \u2013 there are no alternative treatment methods that would lead to an effective cure.<\/jats:p>","DOI":"10.5114\/pjp.2015.51158","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T03:51:43Z","timestamp":1435117903000},"page":"80-85","source":"Crossref","is-referenced-by-count":0,"title":["Case report&lt;br&gt;Uncontrolled human papilloma virus infection in a\u00a028-year-old man leading to death \u2013 case report and review of literature"],"prefix":"10.5114","volume":"66","author":[{"given":"Bartosz","family":"Szybiak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Marsza\u0142ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"\u0141uczewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Golusi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Pazdrowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Majchrzak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Pie\u0144kowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Golusi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2015,5,4]]},"container-title":["Polish Journal of Pathology"],"original-title":[],"link":[{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-54639-137106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-54639-137106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:41:14Z","timestamp":1782207674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polishjournalofpathology.com\/Case-report-Uncontrolled-human-papilloma-virus-infection-in-a-28-year-old-man-leading,54639,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,4]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015]]}},"alternative-id":["54639"],"URL":"https:\/\/doi.org\/10.5114\/pjp.2015.51158","relation":{},"ISSN":["1233-9687","2084-9869"],"issn-type":[{"value":"1233-9687","type":"print"},{"value":"2084-9869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,4]]}}}