{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:53:42Z","timestamp":1782208422425,"version":"3.54.5"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>Our study aimed to compare the histological tumour type and Nottingham histological grade of invasive tumour foci in multifocal\/multicentric breast carcinomas with those in corresponding axillary lymph node (LN) metastases. &lt;br \/&gt;\nWe reassessed slides from consecutive multiple breast carcinomas surgically treated with axillary LN dissection (2007-2012). &lt;br \/&gt;\n155 (19.23%) of 806 cases had multiple breast cancer, of which 115 (74.19%) cases had identical morphology. Of these, 85 (73.91%) cases had axillary LN metastases morphologically identical to the originating breast tumours. 32 of the 40 (80%) cases with different morphology had axillary LN metastases; in most heterogeneous cases with differences in grade (87.5%), the grade of metastases was identical to the grade of the tumour foci with the highest histological grade, and in 33.33% of cases the grade in LN was concordant with the grade of smaller foci. Among the 18 cases heterogeneous in histological type with axillary metastases, 33.33% presented heterogeneous histological types in LN, and 22.22% of them were only concordant with the histological type of the smaller tumour foci. &lt;br \/&gt;\nThe morphological aspects of axillary LN metastases correspond to the highest histological grade and\/or histological tumour type with unfavourable prognosis, which does not necessarily appear in the largest tumour focus.<\/jats:p>","DOI":"10.5114\/pjp.2015.53008","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T07:24:33Z","timestamp":1444202673000},"page":"125-132","source":"Crossref","is-referenced-by-count":14,"title":["Original paper&lt;br&gt;Multifocal\/multicentric breast carcinomas showing intertumoural heterogeneity: a comparison of histological tumour type and Nottingham histological grade of primary tumour and lymph node metastasis"],"prefix":"10.5114","volume":"66","author":[{"given":"Monica","family":"Boros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Podoleanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rares","family":"Georgescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosmin","family":"Moldovan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calin","family":"Molnar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Stolnicu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2015,7,28]]},"container-title":["Polish Journal of Pathology"],"original-title":[],"link":[{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-54627-137083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-54627-137083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:41:29Z","timestamp":1782207689000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polishjournalofpathology.com\/Original-paper-Multifocal-multicentric-breast-carcinomas-showing-intertumoural-heterogeneity,54627,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,28]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015]]}},"alternative-id":["54627"],"URL":"https:\/\/doi.org\/10.5114\/pjp.2015.53008","relation":{},"ISSN":["1233-9687","2084-9869"],"issn-type":[{"value":"1233-9687","type":"print"},{"value":"2084-9869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,28]]}}}