{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:46:58Z","timestamp":1782211618523,"version":"3.54.5"},"reference-count":25,"publisher":"Termedia Sp. z.o.o.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>The genesis of lipoleiomyoma has not been explained yet. Immunohistochemical examinations were performed on 17 lipoleiomyomas in women aged 43-82 (mean age: 51 \u00b19 years). Four types of myomas were distinguished: 1) pure leiomyoma, 2) fibroleiomyoma, 3) hyalinizing leiomyoma, 4) strongly hyalinized myoma, along with three degrees of progression of adipocytic metaplasia: 1) up to 25% of lipocytes, 2) up to 50% of lipocytes, and 3) over 50% of lipocytes in the analyzed sample, along with three degrees of progression of adipocytic metaplasia: 1) up to 25% of lipocytes, 2) up to 50% of lipocytes, and 3) over 50% of lipocytes in the analyzed sample.&lt;br \/&gt;\nA positive correlation was found between the age of women and rate of development of metaplasia (r = 0.51, p = 0.035) as well as with activity of the estrogen receptor in the primary tumor (r = 0.53, p = 0.03).&lt;br \/&gt;\nNew mucous perivascular tissue was reported among 11.8% of patients and on this basis lipocytes were formed.&lt;br \/&gt;\nThe appearance of subendothelial granular cells of large blood vessels with a positive reaction for smooth muscle actin (SMA) and CD68 was reported in 17.7%.&lt;br \/&gt;\nResults of immunohistochemical research seem to confirm that lipocytes de novo come from the primal pluripotent cells of the tumor stroma and not from the fatty degeneration of myocytes.<\/jats:p>","DOI":"10.5114\/pjp.2015.57254","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T04:41:45Z","timestamp":1458621705000},"page":"403-409","source":"Crossref","is-referenced-by-count":2,"title":["Research on genesis of adipocytic metaplasia in uterine fibroids"],"prefix":"10.5114","volume":"66","author":[{"given":"Henryk","family":"So\u015bnik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Jele\u0144","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Kosi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"So\u015bnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2016,2,5]]},"reference":[{"key":"ref-1704834","doi-asserted-by":"crossref","unstructured":"So\u015bnik H, So\u015bnik K. Investigations on uterine fatty lesions. Pol J Pathol 2013; 64: 136-143.","DOI":"10.5114\/pjp.2013.36017"},{"key":"ref-1704835","unstructured":"El Amine El Hadj O, Bonraoui S, Be Fadhel CG, et al. Lipoma of the uterus: clinical and ethiopathological approach of 7 cases with immunohistohemical study of histogenesis. Tunis Med 2010; 88: 916-919."},{"key":"ref-1704836","doi-asserted-by":"crossref","unstructured":"Honor\u00e9 LH. Uterine fibrolipoleiomyoma; Report of a case with discussion of histogenesis. Am J Obstet Gynecol 1978; 15: 635-636.","DOI":"10.1016\/0002-9378(78)90855-4"},{"key":"ref-1704837","doi-asserted-by":"crossref","unstructured":"Aung T, Goto M, Nomoto M, et al. Uterine lipoleiomyoma: a histopathological review of 17 cases. Pathol Int 2004; 54: 751-758.","DOI":"10.1111\/j.1440-1827.2004.01748.x"},{"key":"ref-1704838","unstructured":"\u00d6zdemir O. Mast cells and the tumor-associated neoangiogenesis. Med Sci Monit 2006; 12: LE 9-11."},{"key":"ref-1704839","unstructured":"Takeuchi K, Kitazawa S, Tsujino T, et al. Uterine bizarre epithelioid lipoleiomyoma with a myxoid stroma. Eur J Gynecol Oncol 2006; 27: 273-274."},{"key":"ref-1704840","doi-asserted-by":"crossref","unstructured":"Akbulut M, Soysal ME, Duzcan SE. Giant lipoleiomyoma of the uterine corpus. Arch Gynecol Obstet 2008; 278: 291-293.","DOI":"10.1007\/s00404-008-0580-0"},{"key":"ref-1704841","doi-asserted-by":"crossref","unstructured":"Akpolat I, Sertcelik A, C\u04e7mert S, et al. ERRP-29 and ER staining in uterine lipoma and lipoleiomyoma. Acta Oncol 1996; 35: 108.","DOI":"10.3109\/02841869609098490"},{"key":"ref-1704842","doi-asserted-by":"crossref","unstructured":"Siei\u0144ski W. Lipomatous neometaplasia of the uterus. Report of 11 cases with discussion of histogenesis and pathogenesis. Int J Gynecol Pathol 1989; 8: 357-363.","DOI":"10.1097\/00004347-198912000-00007"},{"key":"ref-1704843","doi-asserted-by":"crossref","unstructured":"Brandfass RT, Everts-Suarez EA. Lipomatous tumors of the uterus. A review of the world\u2019s literature with report of a case of true lipoma. Am J Obstet Gynec 1955; 70: 359-367.","DOI":"10.1016\/S0002-9378(16)37680-3"},{"key":"ref-1704844","unstructured":"Meinhof U, Bersch W. Beitrag zur Kenntnis der fettgewebshaltigen Uterustumoren. Zentralbl Allg Pathol 1975; 119: 369-363."},{"key":"ref-1704845","doi-asserted-by":"crossref","unstructured":"Salm R. The histogenesis of uterine lipomas. Histogenese der Uteruslipome. Beitr Pathol 1973; 149: 284-292.","DOI":"10.1016\/S0005-8165(73)80145-3"},{"key":"ref-1704846","doi-asserted-by":"crossref","unstructured":"Kaiserling E. Immunohistochemical identification of lymph vessels with D2-40 in diagnostic pathology. Pathologe 2004; 25: 362-374.","DOI":"10.1007\/s00292-004-0693-6"},{"key":"ref-1704847","doi-asserted-by":"crossref","unstructured":"Kahn HJ, Bailey D, Marks A. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi\u2019s sarcoma and a subset of angiosarcomas. Mod Pathol 2002; 15: 434-440.","DOI":"10.1038\/modpathol.3880543"},{"key":"ref-1704848","doi-asserted-by":"crossref","unstructured":"Resta L, Maiorano E, Piscitelli D, Botticella MA. Lipomatous tumor of the uterus. Clinico-pathological features of 10 cases with immunocytochemical study of histogenesis. Path Res Pract 1994; 190: 378-383.","DOI":"10.1016\/S0344-0338(11)80410-3"},{"key":"ref-1704849","unstructured":"Scully R. Smooth-muscle differentiation in genital tract disorders (Editorial). Arch Pathol Lab Med 1981; 105: 505-507."},{"key":"ref-1704850","doi-asserted-by":"crossref","unstructured":"Mazur MT, Kraus FT. Histogenesis of morphologic variations in tumor of the uterine wall. 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Nowotwory 1988; 38: 29-34."}],"container-title":["Polish Journal of Pathology"],"original-title":[],"link":[{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-219423-137053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-219423-137053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:51:07Z","timestamp":1782208267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polishjournalofpathology.com\/Research-on-genesis-of-adipocytic-metaplasia-in-uterine-fibroids,219423,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,5]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"alternative-id":["219423"],"URL":"https:\/\/doi.org\/10.5114\/pjp.2015.57254","relation":{},"ISSN":["1233-9687","2084-9869"],"issn-type":[{"value":"1233-9687","type":"print"},{"value":"2084-9869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,5]]}}}