{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:48:39Z","timestamp":1782211719256,"version":"3.54.5"},"reference-count":8,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>Encouraged by our previous finding of growth hormone-releasing hormone receptor (GHRH-R) expression in metaplastic and neoplastic apocrine breast epithelium, we examined a small series of skin adnexal tumours with various degrees of apocrine (oxyphilic) differentiation, as well as normal axillary and anogenital apocrine sweat glands, for the expression of GHRH-R.&lt;br \/&gt;\nSections of formalin-fixed paraffin-embedded tissue blocks were immunostained for gross cystic disease fluid protein-15 (GCDFP-15) and androgen receptor (AR), to prove apocrine differentiation and correlate it with areas of GHRH-R expression.&lt;br \/&gt;\nAll but one of 19 tumours with apocrine epithelium and all five benign apocrine glands stained with both anti-GHRH-R antibodies used, each labelling a different domain of the receptor. Non-apocrine areas of the tumours and four eccrine tumours without oxyphilic features did not stain, but most sebaceous glands and some eccrine glands were labelled. &lt;br \/&gt;\nOur data suggest that anti-GHRH-R antibodies highlight apocrine differentiation at extramammary sites also. Although GHRH-R seems to have a sensitivity comparable to classic apocrine markers such as AR and GCDFP-15, it seems to be inferior in specificity. The GHRH-R labelling of apocrine glands and neoplastic epithelium might also interfere with the emerging anti-GHRH targeted treatment of some malignancies acting on these receptors.<\/jats:p>","DOI":"10.5114\/pjp.2018.75336","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T06:43:15Z","timestamp":1538980995000},"page":"48-52","source":"Crossref","is-referenced-by-count":3,"title":["Expression of growth hormone-releasing hormone receptors in apocrine adnexal tumours and apocrine glands of the skin"],"prefix":"10.5114","volume":"69","author":[{"given":"Bence","family":"K\u0151v\u00e1ri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lajos","family":"Kocsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Cserni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2018,5,7]]},"reference":[{"key":"ref-1700457","doi-asserted-by":"crossref","unstructured":"Kazakov DV, Michal M, Kacerovska D, McKee PH. Lesions with predominant apocrine and eccrine differentiation. In: Kazakov DV, Michal M, Kacerovska D, McKee PH. Cutaneous adnexal tumors. Wolters Kluwer Health\/Lippincott Williams & Wilkins, Philadelphia 2012; 1-171.","DOI":"10.1007\/978-0-85729-757-0_9"},{"key":"ref-1700458","unstructured":"Vranic S, Schmitt F, Sapino A, et al. Apocrine carcinoma of the breast: a comprehensive review. Histol Histopathol 2013; 28: 1393-1409."},{"key":"ref-1700459","doi-asserted-by":"crossref","unstructured":"Kah\u00e1n Z, Arencibia JM, Csernus VJ, et al. Expression of growth hormone-releasing hormone (GHRH) messenger ribonucleic acid and the presence of biologically active GHRH in human breast, endometrial, and ovarian cancers. J Clin Endocrinol Metab 1999; 84: 582-589.","DOI":"10.1210\/jc.84.2.582"},{"key":"ref-1700460","doi-asserted-by":"crossref","unstructured":"Barabutis N, Schally AV. Knocking down gene expression for growth hormone-releasing hormone inhibits proliferation of human cancer cell lines. Br J Cancer 2008; 98: 1790-1796.","DOI":"10.1038\/sj.bjc.6604386"},{"key":"ref-1700461","doi-asserted-by":"crossref","unstructured":"K\u0151v\u00e1ri B, Rusz O, Schally AV, et al. Differential immunostaining of various types of breast carcinomas for growth hormone-releasing hormone (GHRH) receptor \u2013 Apocrine epithelium and carcinomas emerging as uniformly positive. APMIS 2014; 122: 824-831.","DOI":"10.1111\/apm.12224"},{"key":"ref-1700462","doi-asserted-by":"crossref","unstructured":"K\u0151v\u00e1ri B, Vranic S, Marchio C, et al. The expression of GHRH and its receptors in breast carcinomas with apocrine differentiation-further evidence of the presence of a GHRH pathway in these tumors. Hum Pathol 2017; 64: 164-170.","DOI":"10.1016\/j.humpath.2017.03.026"},{"key":"ref-1700463","doi-asserted-by":"crossref","unstructured":"Seitz S, Rick FG, Schally AV, et al. Combination of GHRH antagonists and docetaxel shows experimental effectiveness for the treatment of triple-negative breast cancers. Oncol Rep 2013; 30: 413-418.","DOI":"10.3892\/or.2013.2435"},{"key":"ref-1700464","doi-asserted-by":"crossref","unstructured":"Perez R, Schally AV, Popovics P, et al. Antagonistic analogs of growth hormone-releasing hormone increase the efficacy of treatment of triple negative breast cancer in nude mice with doxorubicin; A preclinical study. Oncoscience 2014; 24: 665-673.","DOI":"10.18632\/oncoscience.92"}],"container-title":["Polish Journal of Pathology"],"original-title":[],"link":[{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-80928-136897","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-80928-136897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:11:54Z","timestamp":1782209514000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polishjournalofpathology.com\/Expression-of-growth-hormone-releasing-hormone-receptors-in-apocrine-adnexal-tumours,80928,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,7]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"alternative-id":["80928"],"URL":"https:\/\/doi.org\/10.5114\/pjp.2018.75336","relation":{},"ISSN":["1233-9687","2084-9869"],"issn-type":[{"value":"1233-9687","type":"print"},{"value":"2084-9869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,7]]}}}