{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:49:39Z","timestamp":1782211779754,"version":"3.54.5"},"reference-count":25,"publisher":"Termedia Sp. z.o.o.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>Interstitial cells of\u00a0Cajal (ICC) were first described by Santiago Ramon y Cajal over 100 years ago. They are thought to play an\u00a0important role in the\u00a0regulation of\u00a0gastrointestinal motility. There is increasing evidence that the\u00a0decline in their number in the\u00a0gallbladder wall contributes to the\u00a0formation of\u00a0concrements. The\u00a0aim of\u00a0the\u00a0study was to determine the\u00a0exact location of\u00a0interstitial cells of\u00a0Cajal in the\u00a0gallbladder wall in patients with calculous and non-calculous cholecystitis.  Sixty-eight patients were examined, of\u00a0whom 50 were cases of\u00a0cholelithiasis and 18 were of\u00a0non-calculous cholecystitis. The\u00a0technique of\u00a0immunohistochemistry with the\u00a0CD117 antibody was used to determine the\u00a0cells of\u00a0Cajal, while to distinguish them from mast cells the\u00a0technique with mast cell tryptase (MCT) was applied. Redistribution of\u00a0the\u00a0interstitial cells of\u00a0Cajal from the\u00a0muscle membrane to lamina propria of\u00a0mucous tissue was observed in the\u00a0cases of\u00a0cholelithiasis, while in the\u00a0group of\u00a0non-calculous cholecystitis most of\u00a0the\u00a0ICC was located within the\u00a0muscle tissue.<\/jats:p>","DOI":"10.5114\/pjp.2019.90397","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T10:22:48Z","timestamp":1578651768000},"page":"205-209","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of the ICC location in the gallbladder wall in patients with cholelithiasis and patients with non-calculous changes"],"prefix":"10.5114","volume":"70","author":[{"given":"Joanna","family":"Sp\u0119tana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Lipi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Jele\u0144","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2019,12,8]]},"reference":[{"key":"ref-1697530","doi-asserted-by":"crossref","unstructured":"Pasternak A, Szura M, Gil K, et al. 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