{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:49:54Z","timestamp":1782211794571,"version":"3.54.5"},"reference-count":24,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>MAML2 rearrangements have been previously described for hidradenomas and muco-epidermoid carcinomas (MEC). However, one report showed EWSR1 rearrangement in both tumours. In this study, EWSR1 and MAML2 translocation were investigated in hidradenomas and MECs. &lt;br \/&gt;\nSpecimens from thirteen MECs of\u00a0the\u00a0salivary glands and twenty hidradenomas of\u00a0the\u00a0skin were evaluated. Fluorescence in situ hybridisation (FISH) studies with EWSR1 and MAML2 break-apart probes were used. &lt;br \/&gt;\nForty percent of\u00a0hidradenomas and 84.6% of\u00a0MECs showed a\u00a0positive MAML2 break signal. EWSR1 break signal was absent in hidradenomas. Only two MECs showed positive EWSR1 signal and were, thus, reclassified as clear cell carcinoma (CCC). A\u00a0statistically significant relationship was also observed between clear cells containing hidradenomas and the\u00a0FISH status.&lt;br \/&gt;\nDespite the\u00a0previous study, EWSR1 translocations could not be established in hidradenomas and MECs. The\u00a0study further suggests that evaluation of\u00a0EWSR1 might be obligatory for the\u00a0correct diagnosis of\u00a0MAML2-negative MECs to exclude the chance of\u00a0CCCs. The\u00a0present study also supports the\u00a0notion that MAML2 can be used as a\u00a0marker for hidradenomas and MECs.<\/jats:p>","DOI":"10.5114\/pjp.2020.97017","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T17:10:58Z","timestamp":1595783458000},"page":"99-106","source":"Crossref","is-referenced-by-count":2,"title":["Are there EWSR1 rearranged cutaneous hidradenomas and mucoepidermoid carcinomas of salivary glands? A FISH study and review of the literature"],"prefix":"10.5114","volume":"71","author":[{"given":"Onder","family":"Bozdogan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00e7in","family":"Kadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazan","family":"Bozdogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"ref-1696184","doi-asserted-by":"crossref","unstructured":"Nandeesh BN, Rajalakshmi T. A\u00a0study of\u00a0histopathologic spectrum of\u00a0nodular hidradenoma. Am J Dermatopathol 2012; 34: 461-470.","DOI":"10.1097\/DAD.0b013e31821a4d33"},{"key":"ref-1696185","doi-asserted-by":"crossref","unstructured":"Kuma Y, Yamada Y, Yamamoto H, et al. A\u00a0novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance. Hum Pathol 2017; 70: 55-61.","DOI":"10.1016\/j.humpath.2017.10.004"},{"key":"ref-1696186","doi-asserted-by":"crossref","unstructured":"M\u00f6ller E, Stenman G, Mandahl N, et al. POU5F1, encoding a\u00a0key regulator of\u00a0stem cell pluripotency, is fused to EWSR1 in hidradenoma of\u00a0the\u00a0skin and mucoepidermoid carcinoma of\u00a0the\u00a0salivary glands. J Pathol 2008; 215: 78-86.","DOI":"10.1002\/path.2327"},{"key":"ref-1696187","doi-asserted-by":"crossref","unstructured":"Antonescu CR, Zhang L, Chang NE, et al. EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A\u00a0molecular analysis of\u00a0sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of\u00a0the\u00a0EWSR1 gene. Genes Chromosomes Cancer 2010; 49: 1114-1124.","DOI":"10.1002\/gcc.20819"},{"key":"ref-1696188","doi-asserted-by":"crossref","unstructured":"Hsieh MS, Wang H, Lee YH, et al. Reevaluation of\u00a0MAML2 fusion-negative mucoepidermoid carcinoma: a\u00a0subgroup being actually hyalinizing clear cell carcinoma of\u00a0the\u00a0salivary gland with EWSR1 translocation. Hum Pathol 2017; 61: 9-18.","DOI":"10.1016\/j.humpath.2016.06.029"},{"key":"ref-1696189","doi-asserted-by":"crossref","unstructured":"Zhao YN, Wang X, Liang FH, et al. Hyalinizing clear cell carcinoma of\u00a0salivary glands: A\u00a0retrospective study focused on uncommon morphology, immunohistochemistry, and detection of\u00a0gene fusion using fluorescence in situ hybridization. Pathol Res Pract 2018; 214: 380-384.","DOI":"10.1016\/j.prp.2017.12.021"},{"key":"ref-1696190","unstructured":"Elder DE, et al. WHO Classification of\u00a0Skin Tumours. 4th ed. 2018. IARC Press, Lyon 2018."},{"key":"ref-1696191","doi-asserted-by":"crossref","unstructured":"Qannam A, Bello IO. Comparison of\u00a0histological grading methods in mucoepidermoid carcinoma of\u00a0minor salivary glands. Indian J Pathol Microbiol 2016; 59: 457-462.","DOI":"10.4103\/0377-4929.191765"},{"key":"ref-1696192","doi-asserted-by":"crossref","unstructured":"Russell-Goldman E, Dubuc A, Hanna J. Differential Expression of\u00a0PLAG1 in Apocrine and Eccrine Cutaneous Mixed Tumors: Evidence for Distinct Molecular Pathogenesis. Am J Dermatopathol 2020; 42: 251-257.","DOI":"10.1097\/DAD.0000000000001393"},{"key":"ref-1696193","doi-asserted-by":"crossref","unstructured":"Andersson MK, K\u00f6lby L, Nilsson JA, Stenman G. Clinical, genetic and experimental studies of\u00a0the\u00a0Brooke-Spiegler (CYLD) skin tumor syndrome. J Plast Surg Hand Surg 2019; 53: 71-75.","DOI":"10.1080\/2000656X.2018.1547736"},{"key":"ref-1696194","doi-asserted-by":"crossref","unstructured":"Amin SM, Beattie A, Ling X, et al. Primary Cutaneous Mammary Analog Secretory Carcinoma With ETV6-NTRK3 Translocation. 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