{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:50:27Z","timestamp":1782211827593,"version":"3.54.5"},"reference-count":25,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>Clinical evaluation of\u00a0oral leukoplakia (OL), confirmed by the\u00a0histological evaluation of\u00a0the\u00a0suspected area, provides the\u00a0gold standard for diagnostics of\u00a0this pathology. The aim of present study was to encrypt the significance of the histopathological results (oral intraepithelial neoplasia \u2013 OIN, WHO 2005, Ljubljana classification systems) of OL. The usefulness of osteonectin as a biomarker of changes in the oral cavity epithelium was evaluated. &lt;br \/&gt;\nIRS Score to evaluate osteonectin (SPARC \u2013 secreted protein acidic and rich in cysteine) production in oral mucous tissues was modified, with the\u00a0aim of\u00a0adapting the\u00a0diagnostic measurements to the\u00a0OL cell environment. In total, 37 formalin-fixed, paraffin-embedded (FFPE) blocks from patients with clinically diagnosed OL, and 29 FFPE blocks from patients with OSCC were evaluated. The\u00a0OIN and system from Ljubljana were compared, to adjudicate which was most compatible with WHO 2005 histopathological assessment. &lt;br \/&gt;\nIncreased production of\u00a0SPARC was observed, with the\u00a0progression in severity of\u00a0pathological changes in the\u00a0oral mucosa, from simple hyperplasia, through dysplasia, to OSCC. The\u00a0WHO 2005 and the\u00a0OIN classification systems can be applied interchangeably.<\/jats:p>","DOI":"10.5114\/pjp.2020.97021","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T17:10:58Z","timestamp":1595783458000},"page":"138-145","source":"Crossref","is-referenced-by-count":3,"title":["Histopathological assessment of oral leukoplakia. Osteonectin as possible biomarker for further diagnostics"],"prefix":"10.5114","volume":"71","author":[{"given":"Irena","family":"Du\u015b-Ilnicka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Radwan-Oczko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Ha\u0142o\u0144","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"ref-1696313","doi-asserted-by":"crossref","unstructured":"Hassona Y, Scully C, Almangush A, et al. Oral potentially malignant disorders among dental patients: a\u00a0pilot study in Jordan. 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J Cell Physiol 2019; 10.1002\/jcp.28205.","DOI":"10.1002\/jcp.28205"}],"container-title":["Polish Journal of Pathology"],"original-title":[],"link":[{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-219296-136758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-219296-136758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:33:31Z","timestamp":1782210811000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polishjournalofpathology.com\/Histopathological-assessment-of-oral-leukoplakia-Osteonectin-as-possible-biomarker,219296,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,21]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020]]}},"alternative-id":["219296"],"URL":"https:\/\/doi.org\/10.5114\/pjp.2020.97021","relation":{},"ISSN":["1233-9687","2084-9869"],"issn-type":[{"value":"1233-9687","type":"print"},{"value":"2084-9869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,21]]}}}