{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:51:17Z","timestamp":1782211877031,"version":"3.54.5"},"reference-count":15,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>We report a case of a 58-year-old female with microscopic extraovarian sex cord proliferations affecting both Fallopian tubes. Molecular analysis showed likely pathogenic germline missense mutations of the KDM5A and KMT2D genes. However, mutations of other genes, including FOXL2 and STK11, were not detected. Our case represents the 12th case of extraovarian sex cord proliferation reported in the literature to date. This is the first time that a molecular genetic analysis of the lesion has been performed, and it showed a wild-type FOXL2 gene, which represents another argument supporting the estimated benign nature of these rare lesions.<\/jats:p>","DOI":"10.5114\/pjp.2020.97023","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T17:10:58Z","timestamp":1595783458000},"page":"175-180","source":"Crossref","is-referenced-by-count":3,"title":["Microscopic extraovarian sex cord proliferation: report of a case with bilateral Fallopian tube involvement and a comprehensive molecular analysis"],"prefix":"10.5114","volume":"71","author":[{"given":"Pavel","family":"Dundr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"V\u011bckov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Tich\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hojn\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krist\u00fdna","family":"N\u011bmejcov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"B\u00e1rt\u016f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"ref-1696480","doi-asserted-by":"crossref","unstructured":"McCluggage WG, Stewart CJ, Iacobelli J, et al. Microscopic extraovarian sex cord proliferations: an\u00a0undescribed phenomenon. Histopathology 2015; 66: 555-564.","DOI":"10.1111\/his.12580"},{"key":"ref-1696481","doi-asserted-by":"crossref","unstructured":"Pennacchia I, Arena V, Federico F, et al. Microscopic Extraovarian Sex Cord Proliferations: Report of\u00a0the\u00a0Seventh Case With 2 Year Follow-up. Int J Gynecol Pathol 2018; 37: 347-348.","DOI":"10.1097\/PGP.0000000000000404"},{"key":"ref-1696482","doi-asserted-by":"crossref","unstructured":"Longworth A, Ganesan R, Yoong AKH, et al. Microscopic Heterotopic Extraovarian Sex Cord-Stromal Proliferations: Expanding the\u00a0Histologic Spectrum. Int J Gynecol Pathol 2018; 37: 35-43.","DOI":"10.1097\/PGP.0000000000000382"},{"key":"ref-1696483","doi-asserted-by":"crossref","unstructured":"Taylor J, Clarke BA, Hasan NU, et al. Ovarian hilar proliferations resembling Sertoli cell tumours: microscopic neoplasms or non-neoplastic remnants? Histopathology 2016; 68: 596-602.","DOI":"10.1111\/his.12784"},{"key":"ref-1696484","doi-asserted-by":"crossref","unstructured":"Hirschowitz L, Salmons N, Ganesan R. Ovarian hilus cell heterotopia. Int J Gynecol Pathol 2011; 30: 46-52.","DOI":"10.1097\/PGP.0b013e3181eaa1ff"},{"key":"ref-1696485","doi-asserted-by":"crossref","unstructured":"Keitoku M, Konishi I, Nanbu K, et al. Extraovarian sex cord-stromal tumor: case report and review of\u00a0the\u00a0literature. Int J Gynecol Pathol 1997; 16: 180-185.","DOI":"10.1097\/00004347-199704000-00017"},{"key":"ref-1696486","doi-asserted-by":"crossref","unstructured":"Omori M, Kondo T, Fukushima J, et al. Extraovarian Fibroma With Minor Sex Cord Elements: A\u00a0Case Report and Literature Review. Int J Surg Pathol 2017; 25: 472-476.","DOI":"10.1177\/1066896917700727"},{"key":"ref-1696487","doi-asserted-by":"crossref","unstructured":"Shah R, McCluggage WG. Unclassifiable Malignant Extraovarian Sex Cord-Stromal Tumors: Report of\u00a03 Cases and Review of\u00a0Extraovarian Sex Cord-Stromal Tumors. Int J Gynecol Pathol 2017; 36: 438-446.","DOI":"10.1097\/PGP.0000000000000350"},{"key":"ref-1696488","doi-asserted-by":"crossref","unstructured":"Kommoss S, Anglesio MS, Mackenzie R, et al. FOXL2 molecular testing in ovarian neoplasms: diagnostic approach and procedural guidelines. Mod Pathol 2013; 26: 860-867.","DOI":"10.1038\/modpathol.2012.226"},{"key":"ref-1696489","doi-asserted-by":"crossref","unstructured":"Shah SP, Kobel M, Senz J, et al. Mutation of\u00a0FOXL2 in granulosa-cell tumors of\u00a0the\u00a0ovary. N Engl J Med 2009; 360: 2719-2729.","DOI":"10.1056\/NEJMoa0902542"},{"key":"ref-1696490","doi-asserted-by":"crossref","unstructured":"Wang GG, Song J, Wang Z, et al. Haematopoietic malignancies caused by dysregulation of\u00a0a\u00a0chromatin-binding PHD finger. Nature 2009; 459: 847-851.","DOI":"10.1038\/nature08036"},{"key":"ref-1696491","doi-asserted-by":"crossref","unstructured":"Hu D, Jablonowski C, Cheng PH, et al. KDM5A Regulates a\u00a0Translational Program that Controls p53 Protein Expression. iScience 2018; 9: 84-100.","DOI":"10.1016\/j.isci.2018.10.012"},{"key":"ref-1696492","doi-asserted-by":"crossref","unstructured":"Duncan DL, Rambally BS, Lininger RA, et al. Displaced granulosa cells in the\u00a0fallopian tube mistaken for metastatic granulosa cell tumor. Int J Gynecol Pathol 2013; 32: 35-37.","DOI":"10.1097\/PGP.0b013e318253c906"},{"key":"ref-1696493","doi-asserted-by":"crossref","unstructured":"Chui MH, Chapman WB, Clarke BA. Displaced granulosa cells within the\u00a0ovarian stroma in a\u00a0BRCA1 mutation carrier. Int J Gynecol Pathol 2014; 33: 423-424.","DOI":"10.1097\/PGP.0b013e3182a3cd2c"},{"key":"ref-1696494","doi-asserted-by":"crossref","unstructured":"Vydianath B, Ganesan R, McCluggage WG. Displaced granulosa cells in the\u00a0fallopian tube mimicking small cell carcinoma. 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