{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:51:43Z","timestamp":1782211903152,"version":"3.54.5"},"reference-count":12,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>Gastrointestinal type of\u00a0endometrial carcinoma is a\u00a0newly described entity for which clearly defined diagnostic criteria have only recently been published. Among morphologic criteria, gastrointestinal mucinous adenocarcinoma of\u00a0endometrium must not show a\u00a0typical endometrioid component. We present a\u00a0case with morphologic diversity, with areas showing gastric and intestinal differentiation as well as an\u00a0endometrioid-like component. However, the\u00a0endometrioid-like component not only did not show classic squamous metaplasia, but was also MUC6-positive, while the\u00a0positivity for ER\/PR was only focal. The\u00a0recognition of\u00a0gastric\/gastrointestinal differentiation in endometrial carcinomas is best accomplished using both morphology and immunohistochemistry rather than either alone.<\/jats:p>","DOI":"10.5114\/pjp.2021.106446","type":"journal-article","created":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T15:12:10Z","timestamp":1625411530000},"page":"84-86","source":"Crossref","is-referenced-by-count":7,"title":["Endometrial adenocarcinoma with gastrointestinal differentiation \u2013 a newly described entity, with morphologic diversity"],"prefix":"10.5114","volume":"72","author":[{"given":"Simona","family":"Stolnicu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Podoleanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildiko","family":"Orban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozsnyai","family":"Francisc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"ref-1695280","doi-asserted-by":"crossref","unstructured":"Zheng W, Yang GC, Godwin TA, et al. Mucinous adenocarcinoma of\u00a0the\u00a0endometrium with intestinal differentiation: a\u00a0case report. Hum Pathol 1995; 26: 1385-1388.","DOI":"10.1016\/0046-8177(95)90307-0"},{"key":"ref-1695281","doi-asserted-by":"crossref","unstructured":"Abiko K, Baba T, Ogawa M, et al. Minimal deviation mucinous adenocarcinoma (\u201cadenoma malignum\u201d) of\u00a0the\u00a0uterine corpus. Pathol Int 2010; 60: 42-47.","DOI":"10.1111\/j.1440-1827.2009.02473.x"},{"key":"ref-1695282","doi-asserted-by":"crossref","unstructured":"Buell-Gutbrod R, Sung CJ, Lawrence WD, et al. Endometrioid adenocarcinoma with simultaneous endocervical and intestinal-type mucinous differentiation: report of\u00a0a\u00a0rare phenomenon and the\u00a0immunohistochemical profile. Diagn Pathol 2013; 8: 128.","DOI":"10.1186\/1746-1596-8-128"},{"key":"ref-1695283","doi-asserted-by":"crossref","unstructured":"Hino M, Yamaguchi K, Abiko K, et al. Magnetic resonance imaging findings and prognosis of\u00a0gastric-type mucinous adenocarcinoma (minimal deviation adenocarcinoma or adenoma malignum) of\u00a0the\u00a0uterine corpus: two case reports. Mol Clin Oncol 2016; 4: 699-704.","DOI":"10.3892\/mco.2016.789"},{"key":"ref-1695284","doi-asserted-by":"crossref","unstructured":"Rubio A, Schuldt M, Guarch R, et al. Pseudomyxoma-type invasion in gastrointestinal adenocarcinomas of\u00a0endometrium and cervix: a\u00a0report of\u00a02 cases. Int J Gynecol Pathol 2016; 35: 118-122.","DOI":"10.1097\/PGP.0000000000000227"},{"key":"ref-1695285","doi-asserted-by":"crossref","unstructured":"McCarthy WA, Makhijani R, Miller K, et al. Gastric-type endometrial adenocarcinoma: report of\u00a0two cases in patients from the\u00a0United States. Int J Surg Pathol 2018; 26: 377-381.","DOI":"10.1177\/1066896917743010"},{"key":"ref-1695286","unstructured":"Wong RWC, Ralte A, Grondin K, et al. Endometrial gastric (gastrointestinal)-type mucinous lesions. Report of\u00a0a\u00a0series illustrating the\u00a0spectrum of\u00a0benign and malignant lesions. Am."},{"key":"ref-1695287","doi-asserted-by":"crossref","unstructured":"J Surg Pathol 2020; 44: 406-419.","DOI":"10.1007\/s00266-020-01609-1"},{"key":"ref-1695288","unstructured":"WHO Classification of\u00a0Tumors: Female Genital Tumors, 5th edition, IARC, 2020."},{"key":"ref-1695289","unstructured":"Stolnicu S, Barsan I, Hoang L, et al. Diagnostic algorithmic proposal based on comprehensive immunohistochemical evaluation of\u00a0297 invasive endocervical adenocarcinomas. Am J Surg."},{"key":"ref-1695290","unstructured":"Pathol 2018; 42: 989-1000."},{"key":"ref-1695291","doi-asserted-by":"crossref","unstructured":"Stolnicu S, Barsan I, Hoang L, et al. International endocervical adenocarcinoma criteria and classification (IECC): a\u00a0new pathogenetic classification for invasive adenocarcinomas of\u00a0the\u00a0endocervix. Am J Surg Pathol 2018; 42: 214-226.","DOI":"10.1097\/PAS.0000000000000986"}],"container-title":["Polish Journal of Pathology"],"original-title":[],"link":[{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-134262-136723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-134262-136723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:44:19Z","timestamp":1782211459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polishjournalofpathology.com\/Endometrial-adenocarcinoma-with-gastrointestinal-differentiation-a-newly-described,134262,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,31]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"alternative-id":["134262"],"URL":"https:\/\/doi.org\/10.5114\/pjp.2021.106446","relation":{},"ISSN":["1233-9687","2084-9869"],"issn-type":[{"value":"1233-9687","type":"print"},{"value":"2084-9869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,31]]}}}