{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:17:41Z","timestamp":1792304261547,"version":"4.4.0"},"reference-count":10,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>Primary vulvar angiosarcomas have a\u00a0propensity for varied macroscopic and histologic appearance that initially may not suggest a\u00a0vascular malignant neoplasm. Therefore, the\u00a0rarity of\u00a0the\u00a0lesion and it\u2019s morphologic diversity may contribute to the\u00a0high rate of\u00a0misdiagnosis. We present the\u00a0case of\u00a0a\u00a043-year old patient with a\u00a0primary vulvar lesion, initially misdiagnosed as an\u00a0angiofibroma. Microscopic examination of\u00a0the\u00a0recurrence together with immunohistochemical profile were in favor on a\u00a0poorly differentiated angiosarcoma. Early diagnoses can improve prognoses in angiosarcomas and, in the\u00a0case of\u00a0recurrences, as in the\u00a0present case, may lead to changes in therapy.<\/jats:p>","DOI":"10.5114\/pjp.2021.109519","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:16:41Z","timestamp":1776691001000},"page":"167-169","source":"Crossref","is-referenced-by-count":1,"title":["Primary angiosarcoma of the vulva: report of a case misdiagnosed as a benign tumor"],"prefix":"10.5114","volume":"72","author":[{"given":"Simona","family":"Stolnicu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Podoleanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildiko","family":"Orban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavian","family":"Stan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bela","family":"Szabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"ref-1694858","doi-asserted-by":"crossref","unstructured":"Young RJ, Brown NJ, Reed MW, et al. Angiosarcoma. Lancet Oncol 2010; 11: 983-991.","DOI":"10.1016\/S1470-2045(10)70023-1"},{"key":"ref-1694859","doi-asserted-by":"crossref","unstructured":"Davos I, Abell MR. Soft tissue sarcomas of\u00a0vulva. Gynecol Oncol 1976; 4: 70-86.","DOI":"10.1016\/0090-8258(76)90009-3"},{"key":"ref-1694860","doi-asserted-by":"crossref","unstructured":"Nirenberg A, Ostor AG, Slavin J, et al. Primary vulvar sarcomas. Int J Gynecol Pathol 1995; 14: 55-62.","DOI":"10.1097\/00004347-199501000-00010"},{"key":"ref-1694861","doi-asserted-by":"crossref","unstructured":"Kruse AJ, Sep S, Slangen BFM, et al. Angiosarcomas of\u00a0primary gynecologic origin. A\u00a0clinicopathologic review and quantitative analysis of\u00a0survival. Int J Gynecol Cancer 2014; 24: 4-12.","DOI":"10.1097\/IGC.0000000000000020"},{"key":"ref-1694862","doi-asserted-by":"crossref","unstructured":"Sheinis M, Cesari M, Selk A. Angiosarcoma of\u00a0the\u00a0vulva; a\u00a0case report. J Lower Gen Tract Dis 2016; 20: e6-e7.","DOI":"10.1097\/LGT.0000000000000171"},{"key":"ref-1694863","doi-asserted-by":"crossref","unstructured":"Yost S, Bradish J, Grossheim L, et al. Epithelioid anfiosarcoma of\u00a0the\u00a0vulva: a\u00a0case report. Gynecologic Oncol Reports 2017; 91-93.","DOI":"10.1016\/j.gore.2017.07.010"},{"key":"ref-1694864","doi-asserted-by":"crossref","unstructured":"Laliscia C, Gadducci A, Pollina LE, et al. Angiosarcoma after adjuvant radiotherapy in high-risk squamous cell carcinoma of\u00a0the\u00a0vulva: a\u00a0case report. Menopause Rev 2019; 18: 230-232.","DOI":"10.5114\/pm.2019.93114"},{"key":"ref-1694865","doi-asserted-by":"crossref","unstructured":"Meyer M, Smith ES, Leitao MM. Angiosarcoma of\u00a0the\u00a0vulva following readiation for colorectal cancer. Gynecologic Oncol Reports 2021; 36: 100711.","DOI":"10.1016\/j.gore.2021.100711"},{"key":"ref-1694866","doi-asserted-by":"crossref","unstructured":"Franzcog SH, Uitterhoeve LJ, Schilthuis MS, et al. Sarcoma in association with multimodality management of\u00a0vulvar cancer: tow case reprts. Gynecol Oncol 2001; 81: 320-323.","DOI":"10.1006\/gyno.2001.6139"},{"key":"ref-1694867","doi-asserted-by":"crossref","unstructured":"Hart J, Mandavilli S. Epithelioid angiosarcoma: a\u00a0brief diagnostic review and differential diagnosis. Arch Pathol Lab Med 2011; 135: 268-272.","DOI":"10.5858\/135.2.268"}],"container-title":["Polish Journal of Pathology"],"original-title":[],"link":[{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-136089-136709","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-136089-136709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:43:49Z","timestamp":1782211429000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polishjournalofpathology.com\/Primary-angiosarcoma-of-the-vulva-report-of-a-case-misdiagnosed-as-a-benign-tumor,136089,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,30]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"alternative-id":["136089"],"URL":"https:\/\/doi.org\/10.5114\/pjp.2021.109519","relation":{},"ISSN":["1233-9687","2084-9869"],"issn-type":[{"value":"1233-9687","type":"print"},{"value":"2084-9869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,30]]}}}