{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:53:53Z","timestamp":1791590033521,"version":"4.3.4"},"reference-count":14,"publisher":"Termedia Sp. z.o.o.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>The disease entity of TFEB-amplified renal cell carcinoma (RCC) has been recently established. In this article, we review such cases. Clinically, the age of patients ranged from 28 to 83 years with a mean age of 62.8 years. The size of the tumor ranged from 1.9 to 19.5 cm with a mean size of 8.7 cm. The tumor demonstrated a variety of architectural patterns such as solid, alveolar, papillary, pseudopapillary, nested or tubular. The International Society of Urological Pathology (ISUP) grade usually corresponds to grade 3 or 4. Cytomorphology shows eosinophilic, clear, amphophilic or even oncocytic cytoplasm. Necrosis can be frequently observed. Neoplastic cells with TFEB-amplified RCC show diffuse or patchy positivity for TFEB. Fluorescence in situ hybridization frequently show the amplification of more than 10 or 20 copies of the TFEB gene. Most TFEB-amplified RCCs behave in an aggressive fashion. Metastasis frequently occurs. In conclusion, this tumor seems to be characterized by occurrence in older patients, frequent necrosis, papillary\/pseudopapillary growth pattern, high-grade nuclear grade, TFEB gene amplification, and aggressive clinical behavior. In order to clarify whether this tumor is a distinct entity from previously described renal tumors or not, a further examination in a large scale study will be required in the future.<\/jats:p>","DOI":"10.5114\/pjp.2021.111769","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T04:38:20Z","timestamp":1642653500000},"page":"197-199","source":"Crossref","is-referenced-by-count":9,"title":["Review of TFEB-amplified renal cell carcinoma with focus on clinical and pathobiological aspects"],"prefix":"10.5114","volume":"72","author":[{"given":"Naoto","family":"Kuroda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Sugawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Ohe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiyoshi","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riuko","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Mikami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Nagashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kvetoslava","family":"Peckova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Michal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondrej","family":"Hes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"ref-1694234","doi-asserted-by":"crossref","unstructured":"Peckova K, Vanecek T, Martinek P, et al. Aggressive and nonaggressive translocation t(6;11) renal cell carcinoma: comparative study of 6 cases and review of the literature. Ann Diagn Pathol 2014; 18: 351-357.","DOI":"10.1016\/j.anndiagpath.2014.10.002"},{"key":"ref-1694235","doi-asserted-by":"crossref","unstructured":"Lilleby W, Vlatkovic L, Meza-Zepeda LA, et al. Translocational renal cell carcinoma (t(6;11)(p21;q12) with transcription factor EB (TFEB) amplification and an integrated precision approach: a case report. J Med Case Rep 2015; 9: 281.","DOI":"10.1186\/s13256-015-0749-7"},{"key":"ref-1694236","doi-asserted-by":"crossref","unstructured":"Argani P, Reuter VE, Zhang L, et al. TFEB-amplified renal cell carcinomas: An aggressive molecular subset demonstrating variable melanocytic marker expression and morphologic heterogeneity. Am J Surg Pathol 2016; 40: 1484-1495.","DOI":"10.1097\/PAS.0000000000000720"},{"key":"ref-1694237","doi-asserted-by":"crossref","unstructured":"Williamson SR, Grignon DV, Cheng J, et al. Renal cell carcinoma with chromosome 6p amplification including the TFEB gene a novel mechanism of tumor pathogenesis? Am J Surg Pathol 2017; 41: 287-298.","DOI":"10.1097\/PAS.0000000000000776"},{"key":"ref-1694238","doi-asserted-by":"crossref","unstructured":"Gupta S, Johnson SH, Vasmatzis G, et al. TFEB-VEGFA (6p21.1) co-amplified renal cell carcinoma: a distinct entity with potential implications for clinical management. Mod Pathol 2017; 30: 998-1012.","DOI":"10.1038\/modpathol.2017.24"},{"key":"ref-1694239","doi-asserted-by":"crossref","unstructured":"Inamura K. Translocation renal cell carcinoma: An update on clinicopathological and molecular features. Cancers 2017; 9: 111.","DOI":"10.3390\/cancers9090111"},{"key":"ref-1694240","doi-asserted-by":"crossref","unstructured":"Skala SL, Xiao H, Udager AM, et al. Detection of 6 TFEB-amplified renal cell carcinomas and 25 renal cell carcinomas with MITF translocations: systematic morphologic analysis of 85 cases evaluated by clinical TFE3 and TFEB FISH assays. Mod Pathol 2018; 31: 179-197.","DOI":"10.1038\/modpathol.2017.99"},{"key":"ref-1694241","doi-asserted-by":"crossref","unstructured":"Mendel L, Ambrosetti D, Bodokh Y, et al. Comprehensive study of three novel cases of TFEB-amplified renal cell carcinoma and review of the literature: Evidence for a specific entity with poor outcome. Genes Chromosomes Cancer 2018; 57: 99-113.","DOI":"10.1002\/gcc.22513"},{"key":"ref-1694242","doi-asserted-by":"crossref","unstructured":"Kojima F, Kuroda N, Matsuzaki I, et al. Aggressive TFEB-rearranged renal cell carcinoma mimicking chromophobe and clear cell renal cell carcinoma. Pathol Int 2019; 69: 51-53.","DOI":"10.1111\/pin.12744"},{"key":"ref-1694243","doi-asserted-by":"crossref","unstructured":"Andeen NK, Qu X, Antic T, et al. Clinical utility of chromosome genomic array testing for unclassified and advanced-stage renal cell carcinomas. Arch Pathol Lab Med 2019; 143: 494-504.","DOI":"10.5858\/arpa.2018-0104-OA"},{"key":"ref-1694244","doi-asserted-by":"crossref","unstructured":"Wyvekens N, Rechsteiner M, Fritz C. Histological and molecular characterization of TFEB-rearranged renal cell carcinomas. Virchows Arch 2019; 474: 625-631.","DOI":"10.1007\/s00428-019-02526-8"},{"key":"ref-1694245","doi-asserted-by":"crossref","unstructured":"Cali\u00f2 A, Brunelli M, Segala D, et al. VEGFA amplification\/increased gene copy number and VEGFA mRNA expression in renal cell carcinoma with TFEB gene alterations. Mod Pathol 2019; 32: 258-268.","DOI":"10.1038\/s41379-018-0128-1"},{"key":"ref-1694246","doi-asserted-by":"crossref","unstructured":"Cali\u00f2 A, Segala D, Munari E, et al. MiT Family translocation renal cell carcinoma: from the early descriptions to the current knowledge. Cancers 2019; 11: 1110.","DOI":"10.3390\/cancers11081110"},{"key":"ref-1694247","doi-asserted-by":"crossref","unstructured":"Gupta S, Argani P, Jungbluth AA, et al. TFEB expression profiling in renal cell carcinomas clinicopathologic correlations. Am J Surg Pathol 2019; 43: 1445\u20131461.","DOI":"10.1097\/PAS.0000000000001307"}],"container-title":["Polish Journal of Pathology"],"original-title":[],"link":[{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-140559-136688","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-140559-136688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:38:57Z","timestamp":1782211137000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polishjournalofpathology.com\/Review-of-TFEB-amplified-renal-cell-carcinoma-with-focus-on-clinical-and-pathobiological,140559,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,19]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"alternative-id":["140559"],"URL":"https:\/\/doi.org\/10.5114\/pjp.2021.111769","relation":{},"ISSN":["1233-9687","2084-9869"],"issn-type":[{"value":"1233-9687","type":"print"},{"value":"2084-9869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,19]]}}}