{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:47:05Z","timestamp":1782215225442,"version":"3.54.5"},"reference-count":9,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol J Pathol"],"abstract":"<jats:p>Follicular lymphoma (FL) is a\u00a0mature B-cell lymphoma that can transform into a\u00a0more aggressive disease such as diffuse large B-cell lymphoma, Burkitt lymphoma, or precursor B-lymphoblastic leukaemia\/lymphoma. The process of transformation of FL occurs by the acquisition of additional genetic alterations, e.g. c-MYC rearrangement, TP53, and cyclin D1 inactivation. Herein, we describe four such cases of FL that transformed into more aggressive B-cell non-Hodgkin lymphomas within six months of their initial diagnosis. Subsequent testing of c-myc, P53 and cyclin D1 by immunohistochemistry and fluorescence in situ hybridization was done to further analyse their role in the process of transformation.<\/jats:p>","DOI":"10.5114\/pjp.2022.120026","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T09:08:00Z","timestamp":1665047280000},"page":"166-175","source":"Crossref","is-referenced-by-count":0,"title":["Early transformation event from follicular lymphoma: our experience of four cases"],"prefix":"10.5114","volume":"73","author":[{"given":"Anurag","family":"Mehta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diksha","family":"Karki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prathyusha","family":"Gudapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2022,10,4]]},"reference":[{"key":"ref-1693413","doi-asserted-by":"crossref","unstructured":"Geyer JT, Subramaniyam S, Jiang Y, et al. Lymphoblastic transformation of follicular lymphoma: a\u00a0clinicopathologic and molecular analysis of 7 patients. Hum Pathol 2014; 46: 260-271.","DOI":"10.1016\/j.humpath.2014.10.021"},{"key":"ref-1693414","doi-asserted-by":"crossref","unstructured":"Fujimoto A, Ikejiri F, Arakawa F, et al. Simultaneous discordant B-lymphoblastic lymphoma and follicular lymphoma. Am J Clin Pathol 2021; 155: 308-317.","DOI":"10.1093\/ajcp\/aqaa126"},{"key":"ref-1693415","doi-asserted-by":"crossref","unstructured":"Casulo C, Burack WR, Friedberg JW. Transformed follicular non-Hodgkin lymphoma. Blood 2015; 125: 40-47.","DOI":"10.1182\/blood-2014-04-516815"},{"key":"ref-1693416","doi-asserted-by":"crossref","unstructured":"Saxe DF, Persons DL, Wolff DJ, et al. Cytogenetics resource Committee of the College of American Pathologists. Validation of fluorescence in situ hybridization using an analyte-specific reagent for detection of abnormalities involving the mixed lineage leukemia gene. 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Cancer 2018; 124: 4622-4632.","DOI":"10.1002\/cncr.31646"},{"key":"ref-1693420","doi-asserted-by":"crossref","unstructured":"Lossos IS, Gascoyne RD. Transformation of follicular lymphoma. Best Pract Res Clin Haematol 2011;24: 147-163.","DOI":"10.1016\/j.beha.2011.02.006"},{"key":"ref-1693421","doi-asserted-by":"crossref","unstructured":"Young KH, Xie Q, Zhou G, et al. Transformation of follicular lymphoma to precursor B-cell lymphoblastic lymphoma with c-myc gene rearrangement as a\u00a0critical event. Am J Clin Pathol 2008; 129: 157-166.","DOI":"10.1309\/NKK3FEX2BE5L7EKB"}],"container-title":["Polish Journal of Pathology"],"original-title":[],"link":[{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-153504-136666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.polishjournalofpathology.com\/pdf-153504-136666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:52:35Z","timestamp":1782211955000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.polishjournalofpathology.com\/Early-transformation-event-from-follicular-lymphoma-our-experience-of-four-cases,153504,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,4]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"alternative-id":["153504"],"URL":"https:\/\/doi.org\/10.5114\/pjp.2022.120026","relation":{},"ISSN":["1233-9687","2084-9869"],"issn-type":[{"value":"1233-9687","type":"print"},{"value":"2084-9869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,4]]}}}